Abstract
-
1.
Stimulation within the amygdaloid complex elicited two different behavioural and cardiovascular patterns of response. In the awake animal stimulation of the magnocellular part of the basal amygdala resulted in a defence reaction. Stimulation parameters eliciting only the first stage of this behaviour induced a moderate tachycardia and a shortlasting decrease in arterial pressure followed by an increase. Aortic blood flow measured distal to the renal arteries was increased; hence calculated peripheral vascular resistance was decreased. The increase in blood flow was blocked by both atropine sulphate and methyl-atropine.
-
2.
Stimulation of the central amygdala in the awake cat elicited a behaviour which was different from a typical defence reaction. The response appeared to be more similar to attack or a superimposition of attack on the defence reaction. Stimulation of this area with lower stimulus intensities elicited a cardiovascular pattern consisting of tachycardia, which was sensitive to β-blockade, increased arterial pressure, which remained elevated for the entire period of stimulation and increased calculated peripheral resistance. These latter changes were blocked by application of phenoxybenzamine as well as of phentolamine. Moreover, there was a marked post-stimulation bradycardia, which was abolished by application of atropine sulphate.
-
3.
Intravenous administration of sodium pentobarbitone did not alter the cardiovascular patterns induced by stimulation of the central or basal amygdala if the dose of pentobarbitone did not exceed 25 mg/kg. However, stimulus intensities had to be increased by a factor of 2 to 3 in order to elicit comparable cardiovascular responses. If the dose of pentobarbitone exceeded 25 mg/kg, the well-defined cardiovascular patterns elicited by stimulation of the two different amygdaloid nuclei could not be observed. In contrast, stimulation of sites within the ventromedial hypothalamus, performed in the same animal, showed that the cardiovascular responses could be elicited also after application of 40–45mg/kg of pentobarbitone. Hence it is concluded that anaesthetic agents such as pentobarbitone act largely on neuronal elements between the amygdala and hypothalamus.
Similar content being viewed by others
References
Abrahams, V. C., Hilton, S. M., Zbrožyna, A. W.: Active muscle vasodilatation produced by stimulation of the brain stem: its significance in the defence reaction. J. Physiol. (Lond.)154, 491–513 (1960)
Anand, B. K., Dua, S.: Circulatory and respiratory changes induced by electrical stimulation of the limbic system (visceral brain). J. Neurophysiol.19, 393–400 (1956)
Andén, N.-E., Strömbom, U.: Adrenergic receptor blocking agents: effects on central noradrenaline and dopomine receptors and on motor activity. Psychopharmacologia (Berl.)38, 91–103 (1974)
von Baumgarten, R., Kanzow, E., Koepchen, H. P., Timm, F.: Beitrag zur Technik der extra- und intracellulären, sowie der stereotaktischen Mikroableitung im Gehirn. Pflügers Arch. ges. Physiol.271, 245–256 (1960)
Djojosugito, A. M., Folkow, B., Lisander, B., Sparks, H.: Mechanism of escape of skeletal muscle resistance vessels from the influence of sympathetic cholinergic vasodilator fibre activity. Acta Physiol. Scand.72, 148–156 (1968)
Edvinsson, L., Nielsen, K. C., Owman, Ch., West, K. A.: Alteration in intracranial pressure, blood-brain barrier, and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals. Acta Physiol. Scand.82, 527–531 (1971)
Forsyth, R. P., Hoffbrand, B. L.: Redistribution of cardiac output after sodium pentobarbital anaesthesia in the monkey. Am. J. Physiol.218, 214–217 (1970)
Heinemann, H., Stock, G., Schaefer, H.: Temporal correlation of responses in blood pressure and motor reaction under electrical stimulation of limbic structures in unanaesthetized, unrestrained cats. Pflügers Arch.343, 27–40 (1973)
Herz, A., Teschemacher, H., Hofstetter, A., Kurz, H.: The importance of lipid-solubility for the central action of cholinolytic drugs. Int. J. Neuropharmacol.4, 207–218 (1965)
Hilton, S. M.: Ways of viewing the central nervous control of the circulation — old and new. Brain Res.87, 213–219 (1975)
Hilton, S. M., Zbrožyna, A. W.: Defence reaction from the amygdala and its afferent and efferent connections. J. Physiol. (Lond.)165, 160–173 (1963)
Kaada, B. R.: Somatomotor, autonomic and electrocorticographic responses to electrical stimulation of ‘rhinencephalic’ and other structures in primates, cat and dog. Acta Physiol. Scand.24, Suppl. 83, 1–285 (1951)
Kaada, B. R.: Stimulation and regional ablation of the amygdaloid complex with reference to functional representation. In: The neurobiology of the amygdala. Advances in behavioural biology, Vol. 2 (B. D. Eleftheriou, ed.), pp. 105–281. New York-London: Plenum Press 1972
Klüver, H., Barrera, E.: A method for the combined staining of cells and fibres in the nervous system. J. Neuropath. exp. Neurol.12, 400–403 (1953)
Klüver, H., Bucy, P. C.: “Psychic blindness” and other symptoms following bilateral lobectomy in rhesus monkeys. Am. J. Physiol.119, 352–353 (1937)
Koikegami, H., Kimoto, A., Kido, C.: Studies on the amygdaloid nuclei and periamygdaloid cortex. Experiments on the influence of their stimulation upon motility of small intestine and blood pressure. Folia Psychiat. Neurol. Jap.7, 87–108 (1953)
Leyhausen, P.: Verhaltensstudien an Katzen. Berlin-Hamburg: Parey 1973
MacLean, P. D.: Psychosomatic disease and the “visceral brain”. Psychosom. Med.11, 338–353 (1949)
MacLean, P. D.: Some psychiatric implications of physiological studies on fronto-temporal portion of limbic system (visceral brain). Electroencephalogr. Clin. Neurophysiol.4, 407–418 (1952)
MacLean, P. D.: Contrasting functions of limbic and neocortical systems of the brain and their relevance to psychophysiological aspects of medicine. Am. J. Med.25, 611–626 (1958)
Mogenson, G. J., Calaresu, F. R.: Cardiovascular responses to electrical stimulation of the amygdala in the rat. Exp. Neurol.39, 166–180 (1973)
Morin, G., Naquet, R., Badier, M.: Stimulation électrique de la région amygdalienne et pression artérielle chez le chat. J. Physiol. (Paris)44, 303–305 (1952)
Price, H. L.: General anaesthesia and circulatory homeostasis. Physiol. Rev.40, 187–218 (1960)
Reinoso-Suarez, F.: Topographischer Hirnatlas der Katze für experimental-physiologische Untersuchungen. Darmstadt: E. Merck AG 1961
Schlör, K. H., Heidt, H., Buss, J., Stock, G.: The influence of the amygdaloid complex on cardiovascular parameters. Pflügers Arch.395, R73 (1975)
Timms, R. J.: The use of anaesthetic steroids alphaxalone-alphadalone in studies of the forebrain in the cat. J. Physiol. (Lond.)256, 71P-72P (1976)
Torii, S., Kawamura, H.: Effects of amygdaloid stimulation on blood pressure and electrical activity of the hippocampus. Jap. J. Physiol.10, 374–384 (1960)
Author information
Authors and Affiliations
Additional information
Supported by grants from the Deutsche Forschungsgemeinschaft within the SFB 90
Rights and permissions
About this article
Cite this article
Stock, G., Schlör, K.H., Heidt, H. et al. Psychomotor behaviour and cardiovascular patterns during stimulation of the amygdala. Pflugers Arch. 376, 177–184 (1978). https://doi.org/10.1007/BF00581581
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00581581