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Effect of splanchnicotomy on the renal excretion of para-aminohippuric acid in the anaesthetized dog

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Summary

Renal excretion of para-aminohippuric acid (PAH) was studied during PAH loading on unilaterally splanchnicotomized (“denervated”) anaesthetized dogs. Urine flow, sodium excretion of denervated kidneys were significantly increased. Below a plasma concentration of 20 mg% there were no differences between intact and denervated kidneys in urinary excretion and in calculated tubular transport of PAH. However, maximum secretion rate on the splanchnicotomized side was significantly decreased (innervated: 34.8, denervated: 25.2 mg/100 ml GFR, respectively). Although both Na reabsorption and PAH secretion are impaired by denervation, the exact mechanism of action of renal sympathectomy is not elucidated as yet.

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Authors and Affiliations

  1. Second Department of Medicine, Semmelweis University Medical School, Szentkirályi u. 46, H-1088, Budapest, Hungary

    László Szalay, Pál Bencsáth & Lajos Takács

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  1. László Szalay
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  2. Pál Bencsáth
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  3. Lajos Takács
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Szalay, L., Bencsáth, P. & Takács, L. Effect of splanchnicotomy on the renal excretion of para-aminohippuric acid in the anaesthetized dog. Pflugers Arch. 367, 287–290 (1977). https://doi.org/10.1007/BF00581368

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