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pH dependence of phosphate reabsorption in the proximal tubule of rat kidney

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Summary

Early loops of the proximal convoluted tubule of parathyroidectomized rats (PTX-rats) were microperfused with a phosphate (4 mM) containing perfusate. With a perfusion solution of pH around 7.45 as estimated as anion deficit theP i reabsorption was two times greater than with a perfusion solution of pH around 6.85. TheP i reabsorption is reduced in PTX-rats made chronic alkalotic (PTX-cA-rats) but the same pH dependence ofP i reabsorption was found. The data indicate that the divalent phosphate is preferentially reabsorbed.

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References

  1. Agus, Z. S., Gardener, L. B., Beck, L. H., Goldberg, M.: Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium and phosphate. Amer. J. Physiol.224, 1143–1148 (1973)

    CAS  PubMed  Google Scholar 

  2. Agus, Z. S., Puschett, J. B., Senesky, D., Goldberg, M.: Mode of action of parathyroid hormone and cyclic adenosine 3′,5′-monophosphate on renal tubular phosphate reabsorption in the dog. J. clin. Invest.50, 617–626 (1971)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Bank, N., Aynedjian, H. S., Weinstein, S. W.: A microperfusion study of phosphate reabsorption by the rat proximal renal tubule. Effect of parathyroid hormone. J. clin. Invest.54, 1040–1048 (1974)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Baumann, K., de Rouffignac, C., Roinel, N., Rumrich, G., Ullrich, K. J.: Renal phosphate transport: Inhomogeneity of local proximal transport rates and sodium dependence. Pflügers Arch.356, 287–297 (1975)

    Article  CAS  PubMed  Google Scholar 

  5. Brunette, M. G., Taleb, L., Carriere, S.: Effect of parathyroid hormone on phosphate reabsorption along the nephron of the rat. Amer. J. Physiol.225, 1076–1081 (1973)

    CAS  PubMed  Google Scholar 

  6. Carrasquer, G., Brodsky, W. A.: Elimination of transient secretion of phosphate by alkalinization of plasma in dogs. Amer. J. Physiol.201, 499–504 (1961)

    CAS  PubMed  Google Scholar 

  7. Frömter, E.: Electrophysiology and isotonic fluid absorption of proximal tubules of mammalian kidney. In: Kidney and urinary tract physiology, Ed. K. Thurau, MTP. Int. Rev. Science, Physiol. Ser. I, Vol 6, pp. 1–38 (1974)

  8. Gekle, D.: Der Einfluß von Parathormon auf die Nierenfunktion. Pflügers Arch.323, 96–120 (1971)

    Article  CAS  PubMed  Google Scholar 

  9. Höhmann, B., Frohnert, P. P., Kinne, R., Baumann, K.: Proximal tubular lactate transport in rat kidney. A micropuncture study. Kidney Int.5, 261–270 (1974)

    Article  PubMed  Google Scholar 

  10. Le Grimellec, C.: Micropuncture study along the proximal convoluted tubule. Electrolyte reabsorption in first convolutions. Pflügers Arch.354, 133–150 (1975)

    Article  PubMed  Google Scholar 

  11. Lowry, O. H., Roberts, N. R., Leiner, K. Y., Wu, M. L., Farr, A. L.: The quantitative histochemistry of brains. I. Chemical methods. J. biol. Chem.207, 1–17 (1954)

    CAS  PubMed  Google Scholar 

  12. Malnic, G., De Mello-Aires, M.: Kinetic study of bicarbonate reabsorption in proximal tubule of the rat. Amer. J. Physiol.220, 1759–1767 (1971)

    CAS  PubMed  Google Scholar 

  13. Ramsay, J. A., Brown, R. M. J., Croghan, P. C.: Electrometric titration of chloride in small volumes. J. exp. Biol.32, 822–829 (1955)

    CAS  Google Scholar 

  14. Sonnenberg, H., Deetjen, P., Hampel, W.: Methode zur Durchströmung einzelner Nephronabschnitte. Pflügers Arch.278, 669–674 (1964)

    Article  CAS  Google Scholar 

  15. Staum, B. B., Hamburger, R. J., Goldberg, M.: Tracer microinjection study of renal tubular phosphate reabsorption in the rat. J. clin. Invest.51, 2271–2276 (1972)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Strickler, J. C., Thompson, D. D., Klose, R. M., Giebisch, G.: Micropuncture study of inorganic phosphate excretion in the rat. J. clin. Invest.43, 1596–1607 (1964)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Ullrich, K. J., Frömter, E., Baumann, K.: Micropuncture and microanalysis in kidney physiology. In: Laboratory Techniques in Membrane Biophysics, H. Passow and R. Stämpfli, Eds., pp. 106–129. Berlin-Heidelberg-New York: Springer 1969

    Chapter  Google Scholar 

  18. Ullrich, K. J., Hampel, H.: Eine einfache Mikroküvette für Monochromator Zeiss und Beckman Modell DU. Pflügers Arch.268, 177–180 (1958)

    Article  CAS  PubMed  Google Scholar 

  19. Ullrich, K. J., Rumrich, G., Baumann, K.: Renal proximal tubular H+-(glycodiazine) transport: inhomogeneity of local transport rate, dependence on sodium effect of inhibitors and chronic adaptation. Pflügers Arch.357, 149–163 (1975)

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Max-Planck-Institut für Biophysik, Frankfurt/M., Germany

    K. Baumann, G. Rumrich, F. Papavassiliou & S. Klöss

  2. Physiologisches Institut-Zellphysiologie, Universität Hamburg, Grindelallee 117, D-2000, Hamburg, Federal Republic of Germany

    K. Baumann

Authors
  1. K. Baumann
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  2. G. Rumrich
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  3. F. Papavassiliou
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  4. S. Klöss
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Baumann, K., Rumrich, G., Papavassiliou, F. et al. pH dependence of phosphate reabsorption in the proximal tubule of rat kidney. Pflugers Arch. 360, 183–187 (1975). https://doi.org/10.1007/BF00580540

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  • DOI: https://doi.org/10.1007/BF00580540

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