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Apolipoprotein AI-CIII-AIV genetic polymorphisms and coronary heart disease in type 2 diabetes mellitus

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Abstract

The aim of this study was to verify whether or not the increased prevalence of coronary heart disease (CHD) commonly observed in patients with type 2 diabetes mellitus is related to a genetic background involving restriction fragment length polymorphisms (RFLPs) of apolipoproteins. On the basis of a case-control design, 62 type 2 diabetic patients with CHD (confirmed by clinical history and electrocardiogram) and 62 age- and sexmatched diabetic subjects without CHD were enrolled. In each of them RFLPs of the apolipoprotein CIII gene (S1 or S2 allele) and AI promoter region (A or G allele), together with fasting plasma lipids and apolipoproteins levels, were assessed. The rare S2 allele was found significantly (P=0.05) more frequently in patients with CHD, and its related S1S2 genotype was associated with higher plasma levels of total cholesterol (P=0.01), triglycerides (P=0.007) and apo B (P=0.001) than the S1S1 genotype. The A allele was more frequent (P=0.004) in patients without CHD and was associated with lower plasma cholesterol (P=0.0001), low-density lipoprotein (LDL)-cholesterol (P=0.0001) and apo B (P=0.005). The S1/A haplotype was more frequent (P=0.05) in patients without CHD and was associated with the lowest plasma lipid levels. These results suggest that genetic factors, related to the apo AI-CIII-AIV gene cluster, could play a role in the development of CHD in type 2 diabetic patients, probably through modification of their plasma lipid pattern.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Messina, I-98100, Messina, Italy

    L. Rigoli, G. Raimondo, A. Di Benedetto, G. Romano, S. Campo, G. Squadrito & D. Cucinotta

  2. Department of Cellular and Molecular Biology, University of Naples, Naples, Italy

    A. Porcellini & F. Corica

  3. Institute of Internal Medicine and Metabolic Diseases, University of Naples, Naples, Italy

    G. Riccardi

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  1. L. Rigoli
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  2. G. Raimondo
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  3. A. Di Benedetto
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  4. G. Romano
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  8. G. Riccardi
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  9. G. Squadrito
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  10. D. Cucinotta
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Rigoli, L., Raimondo, G., Di Benedetto, A. et al. Apolipoprotein AI-CIII-AIV genetic polymorphisms and coronary heart disease in type 2 diabetes mellitus. Acta Diabetol 32, 251–256 (1995). https://doi.org/10.1007/BF00576258

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  • DOI: https://doi.org/10.1007/BF00576258

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