Abstract
The topographical distribution of oestrogen and progesterone receptors in the human endometrium and Fallopian tube was investigated by an immunocytochemical technique. A gradient of positively stained cells was observed: the highest oestrogen and progesterone receptor content was noted in the fundal part of the uterine cavity and the ampullar region of the Fallopian tube. The observed gradient is in keeping with biological and pathological events that occur in the human mullerian tract, e.g. fecundation, implantation and carcinogenesis.
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Greene GL, Nolan C, Engler JP, Jensen EV (1980) Monoclonal antibodies to human estrogen receptor. Proc Natl Acad Sci USA 77:5115–5119
King WJ, Greene GL (1984) Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells. Nature 307:745–747
Noyes RW, Hertig AT, Rock J (1950) Dating the endometrial biopsy. Fertil Steril 1:3–25
Pollow K, Intraphuvasak J, Manz B, Grill H-J, Pollow B (1981) A comparison of cytoplasmic and nuclear estradiol and progesterone receptors in human Fallopian tube and endometrial tissue. Fertil Steril 36:615–622
Press MF, Greene GL (1984) An immunocytochemical method for demonstrating estrogen receptor in human uterus using monoclonal antibodies to human estrophilin. Lab Invest 50:480–486
Press MF, Greene GL (1988) Immunocytochemical localization of estrogen and progesterone receptors. In: DeLellis RA (ed) Diagnostic immunohistochemistry. Raven Press, New York, p 341
Press MF, Nousek-Goebl NA, Bur M, Greene GL (1986) Estrogen receptor localization in the female genital tract. Am J Pathol 123:280–292
Robertson DM, Mester J, Beilby J, Steele SJ, Kellie AE (1971) The measurement of high-affinity oestradiol receptors in human uterine endometrium and myometrium. Acta Endocrinol 68:534–542
Tsibris JCM, Cazenave CR, Cantor B (1978) Distribution of cytoplasmic estrogen and progesterone receptors in human endometrium. J Obstet Gynecol 132:449–454
Vandekerckhove D, De Boever J, Serreyn R (1988) Steroid hormone receptors in the genital tractus. Recent Res Gynecol Endocrinol 1:366–371
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Coppens, M.T., De Boever, J.G., Dhont, M.A. et al. Topographical distribution of oestrogen and progesterone receptors in the human endometrium and Fallopian tube. Histochemistry 99, 127–131 (1993). https://doi.org/10.1007/BF00571873
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DOI: https://doi.org/10.1007/BF00571873