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A double-blind clinical trial of a β2-adrenergic agonist in stress incontinence

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Abstract

A multicenter double-blind placebo-controlled trial was performed on aβ 2-adrenergic agonist, clenbuterol, in 165 women with stress incontinence. Clenbuterol remarkably improved the stress incontinence, and urodynamically the drug was found to increase the maximal urethral closure pressure. Some side effects were noted, but they were not serious. The results of this trial showed clenbuterol to be a promising drug for the treatment of stress incontinence.

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Authors and Affiliations

  1. Department of Urology, Chiba University School of Medicine, Japan

    K. Yasuda & J. Shimazaki

  2. Department of Urology, Branch Hospital, Faculty of Medicine, University of Tokyo, Japan

    K. Kawabe

  3. Department of Urology, Nihon University School of Medicine, Surugadai Hospital, Japan

    Y. Takimoto

  4. Department of Urology, Nagoya University School of Medicine, Japan

    A. Kondo

  5. Department of Urology, Niigata University School of Medicine, Japan

    R. Takaki

  6. Department of Urology, Tohoku University School of Medicine, Japan

    K. Imabayashi

  7. Department of Urology, Teikyo University School of Medicine, Japan

    A. Toyoshima

  8. Department of Physiology, Tokyometropolitan Institute of Gerontology, Japan

    A. Sato

Authors
  1. K. Yasuda
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  2. K. Kawabe
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  3. Y. Takimoto
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  4. A. Kondo
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  5. R. Takaki
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  6. K. Imabayashi
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  7. A. Toyoshima
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  8. A. Sato
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  9. J. Shimazaki
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Consortia

The Clenbuterol Clinical Research Group

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Yasuda, K., Kawabe, K., Takimoto, Y. et al. A double-blind clinical trial of a β2-adrenergic agonist in stress incontinence. Int Urogynecol J 4, 146–151 (1993). https://doi.org/10.1007/BF00571623

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  • DOI: https://doi.org/10.1007/BF00571623

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