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Doxorubicin concentration time course in the myocardium after single administration to the dog

Possible role in the cardiac effects

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  • Doxorubicin
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Summary

Three hours after i. v. administration of doxorubicin, concentrations of the drug in the myocardium are much higher (about 50 times) and decrease much more slowly (drug still detected 21 days later) than those in the plasma, so that storage results from too early readministration, with possible toxic signs.

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Authors and Affiliations

  1. Department of Medical Pharmacology, Claude Bernard University, F-69373, Lyon Cedex 08, France

    Quadiri Timour, Patrice Nony, Jean Lang, Mohamed Lakhal, Véronique Trillet & Georges Faucon

Authors
  1. Quadiri Timour
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  2. Patrice Nony
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  3. Jean Lang
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  4. Mohamed Lakhal
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  5. Véronique Trillet
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  6. Georges Faucon
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Timour, Q., Nony, P., Lang, J. et al. Doxorubicin concentration time course in the myocardium after single administration to the dog. Cancer Chemother. Pharmacol. 20, 267–269 (1987). https://doi.org/10.1007/BF00570501

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  • DOI: https://doi.org/10.1007/BF00570501

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