Summary
The H-Y antigen status was determined in nine transsexual patients. Our results indicate that sexual behaviour is independent of H-Y antigen constitution, in fact all male-to-female transsexual patients typed as H-Y antigen positive, and the female-to-male transsexual patients were H-Y antigen negative.
References
Ciccarese S, Guanti G (1980) Organogenetic function of Daudi cells excreted H-Y antigen on undifferentiated XX human embryonic gonads. Atti AGI Ass Genet Ital XXVI:83–85
Chapelle A de la, Koo GC, Wachtel SS (1978) Recessive sex-determining genes in human XX male syndrome. Cell 15:837–842
Eicher W, Spoljar M, Cleve H, Murken JD, Richter K, Stengel-Rutkowski S (1979) H-Y antigen in transsexuality. Lancet II: 1137–1138
Engel W, Pfafflin F, Wiedeking C (1980) H-Y antigen in transsexuality, and how to explain testis differentiation in H-Y antigen negative males and ovary differentiation in H-Y antigen positive females. Hum Genet 55:315–319
Guanti G, Ciccarese S, Ricco R, Massari S (1981) Testicular feminization: cytogenetic and family studies, H-Y antigen dosage and testis histology. Eur Soc Hum Genet Symposium “Human Behavior and Genetics”: 43. Zurich, March 26–28, 1981
Haseltine FP, Genel M, Crawford JD, Breg WR (1981) H-Y antigen negative patients with testicular tissue and 46,XY karyotype. Hum Genet 57:265–268
Koo GC, Tada N, Chaganti R, Hammerling U (1981) Application of monoclonal anti H-Y antibody for human H-Y typing. Hum Genet 57:64–67
Müller U, Siebers JW, Zenzes MT, Wolf U (1978) The testis as a secretory organ for H-Y antigen. Hum Genet 45:209–213
Ohno S, Ciccarese S, Nagai Y, Wachtel SS (1978) H-Y Antigen in testes of XX(Balb)XY(C3H) chimaeric male mouse. Arch Androl 1: 103–109
Puck MS, Haseltine FP, Francke U (1981) Absence of H-Y antigen in an XY female with campomelic dysplasia. Hum Genet 57:23–27
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Ciccarese, S., Massari, S. & Guanti, G. Sexual behaviour is independent of H-Y antigen constitution. Hum Genet 60, 371–372 (1982). https://doi.org/10.1007/BF00569222
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DOI: https://doi.org/10.1007/BF00569222