Summary
The binding of diphenylhydantoin, imipramine, diazoxide, cephalothin and cephaloglycin to adult and cord plasma is compared. The free (unbound) fraction of diphenylhydantoin, imipramine and diazoxide in cord plasma is greater than in adult plasma. Although total protein concentration of cord plasma is significantly lower than in adult plasma, this does not satisfactorily explain the lesser binding of these drugs to cord plasma.
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Supported in part by NIGMS Grants 14270 and 1543. Presented in part at the Society for Pediatric Research, Atlantic City, N. J., April 1971.
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Pruitt, A.W., Dayton, P.G. A comparison of the binding of drugs to adult and cord plasma. Eur J Clin Pharmacol 4, 59–62 (1971). https://doi.org/10.1007/BF00568901
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DOI: https://doi.org/10.1007/BF00568901