Summary
General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readily obtainable using disposition and input functions.
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Vaughan, D.P., Mallard, D.J.H., Trainor, A. et al. General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments. Eur J Clin Pharmacol 8, 141–148 (1975). https://doi.org/10.1007/BF00561564
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DOI: https://doi.org/10.1007/BF00561564