Summary
The pharmacokinetic profile of miconazole has been studied in normal subjects and in patients suffering from severe renal insufficiency; one group of patients was undergoing intermittent haemodialysis. A three-compartment open model was fitted to the observed plasma concentrations obtained after intravenous infusion of miconazole 522 mg over fifteen minutes. The rate constants of elimination and exchange between compartments computed for the three groups were not significantly different. The apparent volumes of distribution in the cases of renal failure not undergoing haemodialysis were significantly smaller than the corresponding control values. A computational procedure is described which reduces observations obtained after infusion to the case of a single rapid intravenous administration.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brugmans, J., Van Cutsem, J., Heykants, J., Schuermans, V., Thienpont, D.: Systemic antifungal potential, safety and transport of miconazole nitrate. Europ. J. clin. Pharmacol.5 93 - 99 (1972)
Resigno, A., Segre, G.: Drug and tracer kinetics. New York Blaisdell: 1966
Nagashima, R., Levy, G., O'Reilly, R.A.: Comparative pharmacokinetics of coumarin anticoagulants IV. Application of a three-compartmental model to the analysis of the dosedependent kinetics of bishydroxycoumarin elimination. J. pharm. Sci.57 1888 - 1895 (1968)
Lewi, P.J., Heykants, J.J.P., Janssen, P.A.J.: Intravenous pharmacokinetic profile in rats of etomidate. In press, Arch. int. Pharmacodyn. (1976)
Wynants, J., Heykants, J.J.P.: Gaschromatographic determination of miconazole. To be published 1976
Van Landuyt, H.: Microbiological determination of miconazole. To be published 1976
Riggs, D.S.: The mathematical approach to physiological problems. Baltimore: Williams and Wilkins 1963
Lewi, P.J.: Pharmacokinetic program C30. Technical Report Janssen Pharmaceutica 1974
Heykants, J.J.P.: Absorption, metabolism and excretion of miconazole nitrate by human volunteers. Unpublished results 1970
Fabre, J., Balart, L., Chavaz, A.: Acquisitions récentes sur le maniement des médicaments dans l'insuffisance rénale. Actualités Néphrol.15 7 - 29 (1974)
Riff, L.J., Jackson, G.G.: Pharmacology of gentamicin in man. J. infect. Dis.124 (Supl. 124), 98 - 101 (1971)
Thron, C.D.: Linearity and superposition in pharmacokinetics. Pharmacol. Rev.26 3 - 31 (1974)
Nüesch, E.: Proof of the general validity of Dost's law of corresponding areas. Europ. J. clin. Pharmacol.6 33 - 43 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lewi, P.J., Boelaert, J., Daneels, R. et al. Pharmacokinetic profile of intravenous miconazole in man. Eur J Clin Pharmacol 10, 49–54 (1976). https://doi.org/10.1007/BF00561549
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00561549