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The pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis and in patients with chronic renal disease

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Summary

We have studied the pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis, patients with chronic renal failure, and healthy subjects, and have assessed the predictive value of routine tests of liver function and renal function (creatinine clearance) for theophylline and enprofylline total body clearances.

Theophylline clearance was significantly decreased in the patients with liver cirrhosis compared with both the patients with renal failure and the healthy subjects (the mean values in the three groups were 24, 47, and 46 ml·h−1·kg−1 respectively.

Enprofylline clearance was significantly decreased in the patients with chronic renal failure, compared with both the patients with liver cirrhosis and the healthy subjects (the values in the three groups were 64, 250, and 289 ml·h−1·kg−1 respectively.

There was a strong correlation between creatinine clearance and enprofylline clearance, while there was only a poor correlation between the liver function tests and theophylline clearance.

It appears that in various clinical situations enprofylline elimination can be predicted more precisely than theophylline elimination, which may make the drug safer in clinical practice.

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Authors and Affiliations

  1. Department of Pulmonology, State University Groningen, Groningen, The Netherlands

    J. Kraan & G. H. Koëter

  2. Department of Toxicology, State University Groningen, Groningen, The Netherlands

    J. H. G. Jonkman & R. A. de Zeeuw

  3. Department of Hepatology, State University Groningen, Groningen, The Netherlands

    C. H. Gips

  4. Department of Nephrology, State University Groningen, Groningen, The Netherlands

    P. E. de Jong

  5. Department of Lung Function, State University Groningen, Groningen, The Netherlands

    Th. W. van der Mark

  6. Pharma Bio-Research International B.V., Assen, The Netherlands

    J. H. G. Jonkman

  7. AB Draco, Lund, Sweden

    I. Ekman

Authors
  1. J. Kraan
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  2. J. H. G. Jonkman
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  3. G. H. Koëter
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  4. C. H. Gips
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  5. P. E. de Jong
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  6. Th. W. van der Mark
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  7. I. Ekman
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  8. R. A. de Zeeuw
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Kraan, J., Jonkman, J.H.G., Koëter, G.H. et al. The pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis and in patients with chronic renal disease. Eur J Clin Pharmacol 35, 357–362 (1988). https://doi.org/10.1007/BF00561364

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  • DOI: https://doi.org/10.1007/BF00561364

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