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The Influence of Cyproteron-Acetate Orally on the Hair Root Status in Women with Idiopathic Hirsutism

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Summary

The hair root status was used to evaluate the effect of cyproterone-acetate (CA), given orally, on hair cycle in a clinically homogeneous group of 11 women with idiopathic hirsutism.

The therapy was continued for 12 menstrual cycles of treatment. The hair root status on the left upper leg and chin was determined before, directly after CA-treatment and 3 months later.

The absolute number of anagan hair roots in both fields was decreased directly after therapy.

Three months later this value on the upper leg increased again significantly while on the chin there was no significant increase in this period.

The number of catagen/telogen hair roots showed no significant differences before, directly after CA-treatment and 3 months later. The number of regrowing hairs on the upper leg showed a significant increase of dysplastic-dystrophic hair roots.

Zusammenfassung

Der Einfluß einer oralen Therapie des Cyproteronacetates (CA) auf den Haarcyclus bei einer homogenen Gruppe von 11 Frauen mit idiopathischen Hirsutismus wurde mittels Haarstatusuntersuchungen bestimmt. Die Therapie wurde über 12 menstruelle Cyclen fortgesetzt. Der Haarwurzelstatus auf dem linken Oberschenkel und am Kinn wurde vor der Behandlung und sofort nach der CA-Behandlung sowie 3 Monate später bestimmt.

Die absolute Anzahl der anagenen Haarwurzeln in beiden Regionen hatte sich sofort nach Stop der CA-Behandlung vermindert. Drei Monate später war auf dem Oberschenkel eine signifikante Zunahme zu verzeichnen, während am Kinn keine signifikante Veränderung der Zahl der anagenen Haarwurzeln festzustellen war.

Die Zahl der katagenen/telogenen Haarwurzeln zeigte keine signifikante Differenz vor, sofort und 3 Monate nach der Behandlung.

Eine signifikante Zunahme der dysplastischen/dystrophischen Haarwurzeln wurde in den heranwachsenden Haaren des Unterschenkels gefunden.

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Authors and Affiliations

  1. Department of Dermatology, Erasmus University, Faculty of Medicine, Rotterdam, The Netherlands

    J. D. R. Peereboom-Wynia & C. H. Beek

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  1. J. D. R. Peereboom-Wynia
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  2. C. H. Beek
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Peereboom-Wynia, J.D.R., Beek, C.H. The Influence of Cyproteron-Acetate Orally on the Hair Root Status in Women with Idiopathic Hirsutism. Arch. Derm. Res. 260, 137–142 (1977). https://doi.org/10.1007/BF00561118

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  • DOI: https://doi.org/10.1007/BF00561118

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