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Altered nucleosome spacing associated with down syndrome

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Abstract

Micrococcal nuclease digestions of human leukocytes were analyzed using gel electrophoresis. The relative size (or average number of nucleotides) of nucleosomes was determined. The mean nucleosome size of the normal 46 chromosome karyotype is 185±2 bp. There was no significant variation in nucleosome size within the normal population due to age, sex, or race. The mean nucleosome size of the Down syndrome samples is 173±3 bp. These two groups have separate normal distribution curves which do not overlap and are significantly different atP<0.1%.

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Authors and Affiliations

  1. Department of Biological Sciences, 235 Biology Hall, Wright State University, 45435, Dayton, Ohio

    Nicole H. Kahmann & A. V. Rake

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  1. Nicole H. Kahmann
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  2. A. V. Rake
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Kahmann, N.H., Rake, A.V. Altered nucleosome spacing associated with down syndrome. Biochem Genet 31, 207–214 (1993). https://doi.org/10.1007/BF00557329

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  • DOI: https://doi.org/10.1007/BF00557329

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