Skip to main content
SpringerLink
Log in

Effects of cardioselective and non-cardioselective beta-blockade on adrenaline-induced metabolic and cardiovascular responses in man

  • Originals
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

In 12 normal volunteers the interaction between the metabolic and cardiovascular effects of adrenaline and either a cardioselective (atenolol 150 mg p. o. for 1 week) or a non-selectiveβ-blocker with intrinsic sympathomimetic activity (pindolol 15 mg p. o. for 1 week) were studied.

Equiactive doses of theβ-blockers were investigated with respect to their metabolic effects. There were profound differences in the metabolic profile of the two substances: the non-cardioselective beta-blocker caused significant inhibition of the lipolytic, glycogenolytic and the growth hormone-releasing effects of adrenaline when compared to the cardioselective agent. The results indicate that, during non-cardioselective beta-blockade, metabolic effects occur which should favourably influence myocardial oxygen consumption by making myocardial performance more economical.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hirth-Schmidt H, Raptis S, Schröder KE, Pfeiffer EF (1973) Die Wirkung der Beta-Rezeptorenblocker Pindolol (LB 46) und beta-adrenol (Kl 255) auf die durch Arginin und Muskelarbeit induzierte Wachstumshormonsekretion beim Menschen. In: Beringer A (ed) Diabetes mellitus. Maudrich, München, pp 781–786

    Google Scholar 

  2. Raptis S, Hirth-Schmidt H, Schröder KE, Pfeiffer EF (1974) The effect of beta-receptor blockade on exercise and arginine-induced growth hormone secretion in man. Acta Endocrinol (Suppl) 184: Abstract 6

  3. Mjøs OD (1971) Effect of free fatty acids on myocardial function and oxygen consumption in intact dogs. J Clin Invest 50: 1386–1389

    PubMed  Google Scholar 

  4. Mjøs OD, Bugge-Asperheim B, Kiil F (1972) Factors determining myocardial oxygen consumption (MVO2) during elevation of aortic blood pressure. 2. Relation between MVO2 and free fatty acids. Cardiovasc Res 6: 23–27

    PubMed  Google Scholar 

  5. Challoner DR, Steinberg D (1966): The effect of free fatty acids on the oxygen consumption of the perfused rat heart. Am J Physiol 210: 280–286

    PubMed  CAS  Google Scholar 

  6. Day JL (1975) The metabolic consequences of adrenergic blockade: A review. Metabolism 24: 978–966

    Google Scholar 

  7. Wahlquist ML, Kaijser L, Lassers BW, Carlson LA (1973) Fatty acid as a determinant of myocardial substrate and oxygen metabolism in man at rest and during prolonged exercise. Acta Med Scand 193: 89–94

    Article  Google Scholar 

  8. Imura H, Kato Y, Ikeda M, Morimoto M, Yawata M (1971) Effect of adrenergic blocking or stimulating agents on plasma growth hormone, immunoreactive insulin, and blood free fatty acid levels in man. J Clin Invest 50: 1069–1079

    PubMed  CAS  Google Scholar 

  9. Opie LH, Thomas M (1976) Propranolol and experimental myocardial infarction: substrate effects. Postgrad Med J 52 (Suppl): 124–133

    PubMed  Google Scholar 

  10. Young TT (1973) Effect of Propranolol on plasma growth hormone response in insulin-induced hypoglycemia in thyrotoxic patients. J Clin Endocrinol Metab 37: 968–971

    Google Scholar 

  11. Shanis BS, Moshang T (1976) Propranolol and exercise as a screening test for growth hormone deficiency. Pediatrics 57: 712–714

    PubMed  CAS  Google Scholar 

  12. Maclaren NK, Taylor GE, Raiti S (1975) Propranolol-augmented exercise induced human growth hormone release. Pediatrics 56: 804–807

    PubMed  CAS  Google Scholar 

  13. Sutton J, Lazarus L (1974) Effect of adrenergic blocking agents on growth hormone responses to physical exercise. Horm Metab Res 6: 428–429

    PubMed  CAS  Google Scholar 

  14. Syvälahti E, Iisalo E, Leppänen S (1974) The effect of practolol on circulatory response after sympathetic stimulation and on plasma growth hormone and insulin levels. Ann Clin Res 6: 258–265

    PubMed  Google Scholar 

  15. Blackard WG, Heidingsfelder SA (1968) Adrenergic receptor control mechanism for growth hormone secretion. J Clin Invest 47: 1407–1412

    PubMed  CAS  Google Scholar 

  16. Ortigosa JL, Mendoza F, Argota RM, Garcia G, Cervantes C, Parra A (1976) Propranolol effect on plasma glucose, free fatty acid, insulin and growth hormone in Graves' disease. Metabolism 25: 1201–1207

    PubMed  CAS  Google Scholar 

  17. Harms HH, Gooren L, Spoelstra AJG, Hesse C, Verschoor L (1978) Blockade of isoprenaline-induced changes in plasma free fatty acids, immuno-reactive insulin levels and plasma renin acitivity in healthy human subjects, by propranolol, pindolol, practolol, atenolol, metoprolol and acebutolol. Br J Clin Pharmacol 5: 19–26

    PubMed  CAS  Google Scholar 

  18. Lufkin EG, Greene HL, Meek JR, Herman RH (1971) Adrenergic control of hormone secretion. J Lab Clin Med 78: 820–826

    PubMed  CAS  Google Scholar 

  19. Gündogdu AS, Brown PM, Junl S, Sachs L, Sönksen PH (1979) Comparison of hormonal and metabolic effects of salbutamol infusion in normal subjects and insulin-requiring diabetics. Lancet 2: 1321–1329

    Google Scholar 

  20. Levi L (1972) Sympathoadrenomedullary responses to “pleasant” and “unpleasant” psychosocial stimuli. Acta Med Scand 191: (Suppl 528): 55–73

    Google Scholar 

  21. Opie LH (1975) Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction. Am J Cardiol 36: 938–944

    Article  PubMed  CAS  Google Scholar 

  22. Geneva, Helsinki, Sydney and Oslo Declaration published by the World Medical Association (1973) Br Med J 1: 687

    Google Scholar 

  23. Schmidt F (1971) Methoden der Harn- und Blutzuckerbestimmung, Hexokinase G-6-PDH-Verfahren. In: Pfeiffer EF (ed) Handbuch des Diabetes mellitus, Bd 2. Lehmann, München, pp 936–946

    Google Scholar 

  24. Dole VP, Meinerzt H (1960) Microdetermination of long chain acids in plasma and tissues. J Biol Chem 235: 2595–2607

    PubMed  CAS  Google Scholar 

  25. Glick SM, Roth J, Yalow RS, Berson SA (1965): The regulation of growth hormone secretion. Recent Prog Horm Res 21: 241–283

    PubMed  CAS  Google Scholar 

  26. Schröder KE (1971) Radioimmunoassay for Human Growth Hormone: Problems and Characteristics. Horm Metab Res (Suppl) 3: 36–39

    PubMed  Google Scholar 

  27. Wilcoxon F (1945) Individual comparison by ranking methods. Biom Bull 1: 80–83

    Article  Google Scholar 

  28. Thompson JC, Reeder DD, Bunchman HH, Becker HD, Brandt EN (1972) Effect of secretion on circulating gastrin. Ann Surg 176: 384–390

    PubMed  CAS  Google Scholar 

  29. Fain JN (1973) Biochemical aspects of drug and hormone action on adipose tissue. Pharmacol Rev 25: 67–79

    PubMed  CAS  Google Scholar 

  30. Parra A, Schultz RB, Foley TP, Blizzard RM (1970) Plasma GH and adrenergic nervous system: Influence of epinephrine-propranolol infusions on growth hormone release in normal and hypopituitary subjects. J Clin Endocrinol Metab 30: 134–141

    Article  PubMed  CAS  Google Scholar 

  31. Baker L, Barcai A, Kaye R, Haque N (1969) Beta-adrenergic blockade and juvenile diabetes: Acute studies and long-term therapeutic trial. J Pediatr 75: 19–29

    Article  PubMed  CAS  Google Scholar 

  32. Åblad B, Borg KO, Carlsson E, Ek L, Johnsson J, Malmfors T, Regardh CG (1975) A survey of the pharmacological properties of metaprolol in animals and man. Acta Pharmacol Toxicol 36: 7–16

    Article  Google Scholar 

  33. Beinart JW, Cramp DG, Pearson RM, Havard CW (1979) The effect of metoprolol on plasma lipids. Postgrad Med J 55: 709–711

    Article  PubMed  CAS  Google Scholar 

  34. Carlsen JE, Svendsen DL, Christensen NJ, Trap-Jensen J (1980) Rjgnind og adrenerg beta-receptor blokade. Ugeskr Laeg 142: 504–508

    PubMed  CAS  Google Scholar 

  35. Simonsen S, Kjekshus JK (1978) The effect of free fatty acids on myocardial oxygen consumption during atrial pacing and catecholamine infusion in man. Circulation 58: 484–491

    PubMed  CAS  Google Scholar 

  36. Mariko PR, Kjekshus JK, Sobel BE, Watanabe T, Covell JW, Ross J, jr, Braunwald E (1971) Factors influencing infarct size following experimental coronary artery occlusions. Circulation 43: 67–73

    Google Scholar 

  37. Kjekshus JK, Mjøs OD (1973) Effect of inhibition of lipolysis on infarct size after experimental coronary artery occlusion. J Clin Invest 52: 1770–1779

    Article  PubMed  CAS  Google Scholar 

  38. Mjøs OD (1971) Effect of inhibition of lipolysis on myocardial oxygen consumption in the presence of isoproterenol. J Clin Invest 50: 1869–1872

    PubMed  Google Scholar 

  39. Dimsdale JE, Moss J (1980) Plasma catecholamines in stress and exercise. JAMA 243: 340–346

    Article  PubMed  CAS  Google Scholar 

  40. Aberg H (1974) Plasma renin activity after the use of a new beta-adrenergic blocking agent (I.C.I. 66082). Int J Clin Pharmacol 9: 98–100

    PubMed  CAS  Google Scholar 

  41. Svendsen TL, Hartling O, Trap-Jensen J (1979) Immediate haemodynamic effects of propranolol, practolol, pindolol, atenolol and ICI 89406 in healthy volunteers. Eur J Clin Pharmacol 15: 223–228

    Article  PubMed  CAS  Google Scholar 

  42. Pfeiffer EF (1965) Recognized diabetogenic hormones and diabetes in man. In: Leibel BS, Wrenshall GA (eds) On the nature and treatment of diabetes. Excerpta Medica, Amsterdam, pp 368–386

    Google Scholar 

  43. Lundbaek K (1976) Growth hormone's role in diabetic microangiopathy. Diabetes 25 (Suppl 2): 845–849

    PubMed  CAS  Google Scholar 

  44. Ditschuneit H, Petruzzi E, Faulhaber JD, Raptis S, Pfeiffer EF (1968) Der Einfluß körperlicher Belastung auf die Lipolyse bei Fettsüchtigen und potentiellen Diabetikern. Verh Dtsch Ges Inn Med 74: 941–944

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diabetes Center and Artificial Pancreas Unit, Department of Clinical Therapeutics University of Athens, Greece

    S. Raptis, J. Rosenthal, D. Welzel & S. Moulopoulos

  2. Department of Internal Medicine I, University of Ulm, Federal Republic of Germany

    S. Raptis, J. Rosenthal, D. Welzel & S. Moulopoulos

Authors
  1. S. Raptis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Rosenthal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Welzel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Moulopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Raptis, S., Rosenthal, J., Welzel, D. et al. Effects of cardioselective and non-cardioselective beta-blockade on adrenaline-induced metabolic and cardiovascular responses in man. Eur J Clin Pharmacol 20, 17–22 (1981). https://doi.org/10.1007/BF00554661

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00554661

Key words

Search

Navigation