Skip to main content
SpringerLink
Log in

A theoretical investigation of the preferred conformations of glutathione and its constituent amino acid residues

  • Original Investigations
  • Published:
Theoretica chimica acta Aims and scope Submit manuscript

Abstract

The preferred conformations of the tripeptide glutathione have been investigated by performing quantum mechanical calculations using the PCILO method. A series of model compounds representing fragments of the tripeptide has been studied as well as the complete molecule. The results are compared with the available experimental data.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Meister, A., Tate, S.: Ann. Rev. Biochemistry 45, 560 (1976)

    Google Scholar 

  2. Metzler, D. E.: “Biochemistry” 421. New York: Academic Press 1977

    Google Scholar 

  3. Ciba Foundation Symposium 67 (new series): Submolecular biology and cancer. Amsterdam: Excerpta Medica 1979

  4. Diner, S., Malrieu, J. P., Claverie, P.: Theoret. Chim. Acta (Berl.) 13, 1–45, (1969); 15, 100–110 (1969)

    Google Scholar 

  5. Pullman, B., Pullman, A.: Advan. Protein Res. 16, 387 (1974)

    Google Scholar 

  6. Pullman, B., in: Quantum mechanics of molecular conformations, Pullman, B. Ed. New York: Wiley Interscience 1976

    Google Scholar 

  7. IUPAC-1B Commission of Biochemical Nomenclature: J. Mol. Biol. 52, 1 (1970)

    Google Scholar 

  8. Pullman, B., Maigret, B. in: Conformation of Biological Molecules and Polymers 13, Bergman and Pullman, Eds. New York: Academic Press 1973

    Google Scholar 

  9. Scheraga, H. A.: Adv. in Phys. Org. Chem. 6, 103 (1968)

    Google Scholar 

  10. Pople, S. A., Gordon, M.: J. Am. Chem. Soc. 89, 4253 (1967)

    Google Scholar 

  11. Pullman, A.: unpublished work

  12. Pullman, B., Maigret, B.: Theoret. Chim. Acta (Berl.) 35, 113 (1974)

    Google Scholar 

  13. Thomson, C., Laurence, P.: manuscript in preparation

  14. Palla, P., Petrongolo, K., Tomasi, J.: to be published, J. Phys. Chem., Feb 7, 1980

  15. Perahia, D., Pullman, B., Claverie, P.: Intern. J. Quantum Chem. 6, 337 (1972)

    Google Scholar 

  16. Wright, W. B.: Acta Cryst. 11, 632 (1958)

    Google Scholar 

  17. Cole, F. E.: Am. Cryst. Assoc. Summer Meeting 1970, 34

  18. Zenin, S. V., Chuprina, G. I., Krylova, A. Yu.: Zh. Obshchci Khimii, 45, 1337 (1975)

    Google Scholar 

  19. Fujiwara, S., Formicita-Kozlowsita, G., Kozlowski, H.: Bull. Chem. Soc. Japan, 50, 3131 (1977)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Regional Workshop of the National Foundation for Cancer Research, Department of Chemistry, University of St. Andrews, KY16 9ST, St. Andrews, Scotland

    Patricia R. Laurence & Colin Thomson

Authors
  1. Patricia R. Laurence
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Colin Thomson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Laurence, P.R., Thomson, C. A theoretical investigation of the preferred conformations of glutathione and its constituent amino acid residues. Theoret. Chim. Acta 57, 25–41 (1980). https://doi.org/10.1007/BF00547994

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00547994

Key words

Search

Navigation