Summary
A single-centre, open, Phase I-study comparison of the pharmacokinetics of a single dose of metaclazepam 10 mg, a new 1,4-benzodiazepine has been done in 10 older and 20 younger volunteers. No important age-related effect was found on the kinetics of metaclazepam or its N-desmethyl derivative, the principal metabolite in man.
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Molz, K.H., Gielsdorf, W., Rasper, J. et al. Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers. Eur J Clin Pharmacol 29, 247–249 (1985). https://doi.org/10.1007/BF00547431
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DOI: https://doi.org/10.1007/BF00547431