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Glandular neoplasia within the urinary tract. The aetiology of adenocarcinoma of the urothelium with a review of the literature

I. Introduction: The origin of glandular epithelium in the renal pelvis, ureter and bladder

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Summary

The origins of glandular lesions within the urinary drainage tract are discussed, and their development by metaplasia of the urothelium illustrated. Illustrative cases show the development of cystitis cystica and cystitis glandularis: and their relationship to calculi, Esch. coli cystitis, Schist. haematobium infestation, and tumours under the Urothelium are discussed.

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References

  • Abehouse, B. S.: Exstrophy of the bladder, complicated by adenocarcinoma of the bladder and renal calculi. J. Urol. (Baltimore) 49, 259–289 (1943).

    Google Scholar 

  • Aboul Nasr, A. L., Gazayerli, M. D., Fawzi, R. M., El Sabai, I.: Epidemiology and pathology of cancer of the bladder in Egypt. Acta un. int. Cancr. 18, 528–537 (1962).

    Google Scholar 

  • Aiken, D.: Pyelitis glandularis. Brit. J. Surg. 42, 412–416 (1955).

    Google Scholar 

  • Albarran, J.: Les tumeurs de la vessie. Paris: G. Steinheil 1892.

    Google Scholar 

  • Aschoff, L.: Ein Beitrag zur normalen und pathologischen Anatomie der Schleimhaut der Harnwege und ihrer drüsigen Anhänge. Virchows Arch. path. Anat. 138, 119–161 and 195–200 (1894).

    Google Scholar 

  • Baker, W. J.: Cystitis glandularis associated with ureteral stone and ureterocele. Q. Bull. Northw. Univ. med. Sch. 21, 242–244 (1947).

    Google Scholar 

  • Begg, R. C.: The colloid adenocarcinomata of the bladder vault arising from the epithelium of the urachal canal. Brit. J. Surg. 18, 422–466 (1931).

    Google Scholar 

  • Bland Sutton, J.: Psorospermia in ureter. Brit. med. J. 1889II, 1392.

    Google Scholar 

  • Brutt, H.: Über pyelitis glandularis. Z. urol. Chir. 14, 157–162 (1923).

    Google Scholar 

  • Clark, J. J.: A case of psorospermial cysts of the left kidney and ureter and of the bladder with hydronephrosis of the Lt. kidney. Trans. path. Soc. Lond. 43, 94–99 (1892).

    Google Scholar 

  • Colby, F. H.: Embryonic rests in the urinary bladder. Surg. Gynec. Obstet. 40, 528–530 (1925).

    Google Scholar 

  • Cotchin, E.: Spontaneous carcinoma of the urinary bladder of the dog. Brit. vet. J. 115, 431–434 (1959).

    Google Scholar 

  • Dimmette, R. M., Sproat, H. F., Sayegh, E. S.: The classification of carcinoma of the urinary bladder associated with schistosomiasis and metaplasia. J. Urol. (Baltimore) 75, 680–686 (1956).

    Google Scholar 

  • Dodge, O. G.: Tumours of the bladder in Uganda Africans. Acta un. int. Cancr. 18, 548–552 (1962).

    Google Scholar 

  • Enderlen: Zur Histologie der Schleimhaut der ektopierten Blase. Verh. dtsch. path. Ges. 7, 167–170 (1904).

    Google Scholar 

  • Eve, F. S.: Psorospermial cysts of both ureters. Trans. path. Soc. Lond. 40, 444–446 (1889).

    Google Scholar 

  • Feldman, W. H.: Papillary adenoma of the urinary bladder in the ox. Amer. J. Path. 6, 205–208 (1930).

    Google Scholar 

  • Ferguson, A. R.: Associated bilharziosis and primary malignant disease of the urinary bladder with observation of a series of 40 cases. J. Path. Bact. 16, 76–94 (1911).

    Google Scholar 

  • Formiggini, B.: Contributo allo studio istologico della mucosa vesicele extrofica. Rif. med. 36, 252–254 (1920).

    Google Scholar 

  • Francois, J.: Sur la transformation de la cystite Kystique en cystite glandulaire. J. Urol. med. Chir. 4, 207–232 (1913).

    Google Scholar 

  • Giani, R.: Experimenteller Beitrag zur Entstehung der cystitis cystica. Zbl. allg. Path. path. Anat. 17, 180–184 and 900–902 (1906).

    Google Scholar 

  • —— Neuer Experimenteller Beitrag zur Entstehung der cystitis cystica. Beitr. path. Anat. 42, 1–22 (1907).

    Google Scholar 

  • Gillman, J., Prates, M. B.: Histological types and histogenesis of bladder cancer in the Portuguese East African with special reference to bilharzial cystitis. Acta un. int. Cancr. 18, 560–574 (1962).

    Google Scholar 

  • Goebel, C.: Über die bei Bilharziosiskrankheit vorkommenden Blasentumoren mit besonderer Berücksichtigung des Karzinoms. Z. Krebsforsch. 3, 369–513 (1905).

    Google Scholar 

  • Gordon, A.: Intestinal metaplasia of the urinary tract epithelium. J. Path. Bact. 85, 441–444 (1963).

    Google Scholar 

  • Grieve, J.: Contrasting cases of cystitis cystica. Brit. J. Urol. 37, 157–159 (1965).

    Google Scholar 

  • Grogono, J. L., Shepheard, B. F.: Carcinoma of the urachus. Brit. J. Urol. 41, 222–227 (1969).

    Google Scholar 

  • Hache, M.: Pathogénie et variétés de l'exstrophie de la vessie. Rev. Chir. (Paris) 7, 218–227 (1888).

    Google Scholar 

  • Hamilton, W. J., Boyd, J. D., Mossman, H. W.: Development of the bladder. Human embryology, 2nd ed, p. 247. Cambridge: Heffer 1952.

    Google Scholar 

  • Harrison, R.: Specimens of bilharzia affecting the urinary organs. Lancet 1889II, 163.

    Google Scholar 

  • Higginson, J., Oettle, A. G. Cancer of the bladder in the South African Bantu. Acta un. int. Cancr. 18, 579–584 (1962).

    Google Scholar 

  • Johnson, F. R.: Some proliferative and metaplastic changes in transitional epithelium. Brit. J. Urol. 29, 112–120 (1957).

    Google Scholar 

  • Kittredge, W. E., Brannan, W.: Cystitis glandularis. J. Urol. (Baltimore) 81, 419–430 (1959).

    Google Scholar 

  • Krag, D. O., Alcott, D. L.: Glandular metaplasia of the renal pelvis. Amer. J. clin. Path. 27, 672–680 (1957).

    Google Scholar 

  • Langham, R. C., Thorp, F., Hallman, E. T.: Adenoma of the bovine bladder. Amer. J. Path. 20, 421–423 (1944).

    Google Scholar 

  • Lecène, P., Hovelacque, A.: Les cancers développés sur la vessie extrophiée. J. urol. med. chir. 1, 493–502 (1912).

    Google Scholar 

  • Makar, N.: A note on the pathogenesis of cancer in the bilharzial bladder. Brit. J. Surg. 45, 240–250 (1957).

    Google Scholar 

  • —— Some observations on pseudoglandular proliferation in the bilharzial bladder. Acta un. int. Cancr. 18, 599–607 (1962).

    Google Scholar 

  • —— Urquhart, A. L.: Adenoma of the urinary bladder. Brit. J. Urol. 2, 384–387 (1930).

    Google Scholar 

  • Melicow, M. M.: Tumours of the urinary drainage tract: Urothelial tumours. J. Urol. (Baltimore) 54, 186–103 (1945).

    Google Scholar 

  • —— Histological study of vesical urotherlium between gross neoplasms in total cystectomy. J. Urol. (Baltimore) 68, 261–279 (1952).

    Google Scholar 

  • —— Tumours of the urinary bladder: a clinicopathological analysis of over 2500 specimens and biopsies. J. Urol. (Baltimore) 74, 498–521 (1955).

    Google Scholar 

  • Mende, T. J., Chambers, E. L.: Distribution of mucopolysaccharide and alkaline phosphatase in transitional epithelia. J. Histochem. Cytochem. 5, 99–104 (1957).

    Google Scholar 

  • Morgagni, J. B.: The seats and causes of diseases, trans. Benj. Alexander. London: 1769.

  • Morse, H. D.: The aetiology and pathology of pyelitis cystica, ureteritis cystica and cystitis cystica. Amer. J. Path. 4, 33–50 (1928).

    Google Scholar 

  • Mostofi, F. K.: Potentialities of the bladder epithelium. J. Urol. (Baltimore) 71, 705–714 (1954).

    Google Scholar 

  • —— Pathological aspects and spread of carcinoma of the bladder. J. Amer. med. Ass. 206, 1764–1769 (1968).

    Google Scholar 

  • —— Thompson, R. N., Dean, A. L.: Mucous adenocarcinoma of the urinary bladder. Cancer (Philad.) 8, 741–758 (1955).

    Google Scholar 

  • Mugera, G. M., Nderito, P., Sorheim, A. O.: The pathology of urinary bladder tumours in Kenya Zebu cattle. J. comp. Path. 79, 251–254 (1969).

    Google Scholar 

  • Navasquez, S. de: Experimental pyelonephritis in the rabbit produced by staphylococcal infection. J. Path. Bact. 62, 429–436 (1950).

    Google Scholar 

  • Nesbit, R. M.: Is cystitis cystica an innocent or malefic lesion? J. Urol. (Baltimore) 75, 443–447 (1956).

    Google Scholar 

  • Pamukcu, A. M.: Tumours of the urinary bladder in cattle, with special reference to etiology and histogenesis. Acta un. int. Cancr. 18, 625–638 (1962).

    Google Scholar 

  • Parker, C.: Cystitis cystica and glandularis, a study of 40 cases. Proc. roy. Soc. med. 63, 239–241 (1970).

    Google Scholar 

  • Paschkis, R.: Beiträge zur Pathologie des Nierenbeckens. Folia Urol. 7, 55–74 (1912).

    Google Scholar 

  • Patch, F. S., Rhea, L. J.: Genesis and development of Brunn's nests and their relationship to cystitis cystica, cystitis glandularis, and primary adenocarcinoma of the bladder. Canad. med. Ass. J. 33, 597–606 (1935).

    Google Scholar 

  • Pena, A. de la, Oliveros, M., Tamames, J. M., Mintz, S.: Metaplastic and malignant changes of the urothelium. Brit. J. Urol. 31, 473–478 (1959).

    Google Scholar 

  • Pugh, R. C. B.: In Wallace, D. M., Tumours of the bladder, chapt. 10. London: Livingstone 1959.

    Google Scholar 

  • Rewell, R. E., Willis, R. A.: Some tumours of wild animals. J. Path. Bact. 62, 450–452 (1950).

    Google Scholar 

  • Salm, R.: Neoplasia of the bladder and cystitis cystica. Brit. J. Urol. 39, 67–72 (1967).

    Google Scholar 

  • Sandrey, J. G.: Adenocarcinoma of the bladder. Brit. J. Urol. 39, 513–514 (1967).

    Google Scholar 

  • Saphir, O., Kurland, S. K.: Adenocarcinoma of the urinary bladder. Urol. cutan. Rev. 43, 709–719 (1939).

    Google Scholar 

  • Sayegh, E. S., Ishak, K. G.: Adenocarcinoma associated with schistosomiasis in an ectopia vesicae. Report of a case. Brit. J. Surg. 44, 426–429 (1957).

    Google Scholar 

  • Schade, R. O. K., Swinney, J.: Pre-cancerous changes in the bladder epithelium. Lancet 1968 II, 943–946.

    Google Scholar 

  • Scholl, A. J.: Potential malignancy in extrophy of bladder. Ann. Surg. 75, 365–371 (1922).

    Google Scholar 

  • Sharp, H. C.: Primary colloid carcinoma of the bladder. Trans. path. Soc. Lond. 47, 168–169 (1896).

    Google Scholar 

  • Stanley, K. E., Dockerty, M. B.: Clinically significant endometriosis of the urinary tract. Surg. Gynec. Obstet. 120, 491–498 (1965).

    Google Scholar 

  • Stirling, C., Ash, J. E.: Chronic proliferative lesions of the urinary tract. J. Urol. (Baltimore) 45, 342–360 (1941).

    Google Scholar 

  • Stirling, W. C.: Extensive bilateral pyelo-uretero-cystitis cystica and glandularis producing pyonephrosis-nephrectomy. Report of two cases. J. Urol. (Baltimore) 48, 237–243 (1942).

    Google Scholar 

  • Stoerck, O.: Beiträge zur Pathologie der Schleimhaut der harnleitenden Wege. Beitr. z. path. Anat. 26, 367–445 (1899).

    Google Scholar 

  • —— Über Cystitis (pyelitis ureteritis und cystitis) cystica. Beitr. z. path. Anat. 50, 316–397 (1911).

    Google Scholar 

  • Thomas, D. G., Ward, A. M., Williams, J. L.: A study of 52 cases of adenocarcinoma of the bladder. Brit. J. Urol. 43, 3–15 (1971).

    Google Scholar 

  • Torassa, G. L.: Pyelitis glandularis. J. Urol. (Baltimore) 60, 393–397 (1948).

    Google Scholar 

  • Towers, R. P.: Aspects of metaplasia in genitourinary pathology. J. Irish med. Ass. 53, 179–183 (1963).

    Google Scholar 

  • Urquhart, A. L.: Cyst formation of the ureter associated with bilharzia. Brit. J. Urol. 3, 21–25 (1931).

    Google Scholar 

  • Voelker, A.: Chronic interstitial nephritis with cysts in renal pelvis, double ureter and malformation of the bladder. Trans. path. Soc. Lond. 49, 168–169 (1898).

    Google Scholar 

  • Wheeler, J. D., Hill, W. T.: Adenocarcinoma involving the urinary bladder. Cancer (Philad.) 7, 119–135 (1954).

    Google Scholar 

  • Willis, R. A.: In Pathology of tumours 3rd ed. London: Butterworth 1960.

    Google Scholar 

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  1. Department of Pathology, University of Sheffield, England

    A. Milford Ward

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Ward, A.M. Glandular neoplasia within the urinary tract. The aetiology of adenocarcinoma of the urothelium with a review of the literature. Virchows Arch. Abt. A Path. Anat. 352, 296–311 (1971). https://doi.org/10.1007/BF00542714

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