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Plasma protein binding of furosemide in the elderly

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Summary

The protein binding of furosemide was investigated in plasma from 22 old and 11 young subjects by equilibrium dialysis. The unbound fraction of furosemide was 3.16% in plasma from the elderly and 1.71% in plasma from the young. A significant correlation was found between the unbound fraction of furosemide and the plasma concentration of albumin. The average number of binding sites was 3.8 (elderly) and 2.7 (young) 10−6 mol/g albumin. The average association constant (K) was 4.3 (elderly) and 4.2 (young) 105 M−1. By increasing the concentration of furosemide up to 200 µg/ml buffer the unbound fraction of the drug rose to 5.2% (elderly) and 3.5% (young).

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Authors and Affiliations

  1. Department of General Pathology, Medical School, University of Pisa, Pisa, Italy

    G. M. Pacifici & A. Viani

  2. Department of Geriatrics, Medical University, University of Lübeck, Lübeck, Germany

    H. -U. Schulz & H. -J. Frercks

Authors
  1. G. M. Pacifici
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  2. A. Viani
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  3. H. -U. Schulz
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  4. H. -J. Frercks
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Pacifici, G.M., Viani, A., Schulz, H.U. et al. Plasma protein binding of furosemide in the elderly. Eur J Clin Pharmacol 32, 199–202 (1987). https://doi.org/10.1007/BF00542196

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  • DOI: https://doi.org/10.1007/BF00542196

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