Summary
The pharmacokinetics of the antianginal drug isosorbide-5-nitrate (IS-5-N) was studied in 20 patients with varying degrees of chronic renal failure after repeated oral doses of standard 20 mg tablets t.d.s. Blood samples were taken in the steady state on the 2nd and 28th days, and the plasma level was assayed by HPLC. There was no statistically significant difference in C ssmax , t1/2 and AUC ss0–8 between the 2nd and 28th days, nor was a difference found between patients with mild and severe renal failure.
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References
Abshagen U, Betzien G, Endele R, Kaufmann B (1981) Pharmacokinetics of intravenous and oral isosorbide-5-mononitrate. Eur J Clin Pharmacol 20: 269–275
Abshagen U, Spörl-Radun S (1981) First data on effects and pharmacokinetics of isosorbide-5-mononitrate in normal man. Eur J Clin Pharmacol 19: 423–429
Bogaert MG, Rosseel MT, Boelaert J, Daneels R (1981) Fate of isosorbide dinitrate and mononitrates in patients with renal failure. Eur J Clin Pharmacol 21: 73–76
Kösters W, Klotschkoff P, Abshagen U (1981) Pharmakokinetik von Isosorbid-5-Mononitrat bei Patienten mit fortgeschrittener Niereninsuffizienz. Med Welt 32: 521–523
Laufen H, Aumann M, Leitold M (1983) Oral absorption and disposition of isosorbide dinitrate and isosorbide mononitrates in man. Arzneimittelforsch/Drug Res 33: 980–984
Maddock J, Lewis PA, Woodward A, Massey PR, Kennedy S (1983) Determination of isosorbide dinitrate and its mononitrate metabolites in human plasma by high-performance liquid chromatography-thermal energy analysis. J Chromatogr Biomed Appl 272: 129–136
Major RM, Taylor T, Chasseaud LF, Darragh A, Lambe RF (1984) Isosorbide 5-mononitrate kinetics Clin Pharmacol Ther 35: 653–659
Mannebach H, Ohlmeier H, v Möllendorff E, Gleichmann V, Abshagen U (1981) Steady-state-Kinetik von Isosorbid-5-Mononitrat bei Patienten mit koronarer Herzkrankheit. Med Welt 32: 517–520
Steudel HC, Volkenandt M, Steudel AT (1983) Pharmacokinetics of isosorbide-5-mononitrate after oral and intravenous administration in patients with liver cirrhosis: First results. Z Kardiol 72 [Suppl 3]: 24–28
Taylor T, Chasseaud LF, Major R, Doyle E, Darragh A (1981) isosorbide 5-mononitrate pharmacokinetics in humans. Biopharm Drug Dispos 2: 255–263
Wood SG, John BA, Chasseaud LF, Major RM, Forrest ME, Bonn R, Darragh A, Lamb RF (1984) Metabolic fate of 14C-isosorbide 5-mononitrate in humans.) Arzneimittelforsch/Drug Res 34: 1031–1035
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Evers, J., Krakamp, B., Klimkait, W. et al. Pharmacokinetics of isosorbide-5-nitrate in renal failure. Eur J Clin Pharmacol 30, 349–350 (1986). https://doi.org/10.1007/BF00541542
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DOI: https://doi.org/10.1007/BF00541542