Skip to main content
SpringerLink
Log in

Human lymphocyte response to selected infectious agents in Reiter's syndrome and ankylosing spondylitis

  • Originals
  • Published:
Rheumatology International Aims and scope Submit manuscript

Summary

Reiter's syndrome (RS) and idiopathic ankylosing spondylitis (AS) have been associated with certain infections and the histocompatibility antigen HLA-B27. The proliferative responses of peripheral mononuclear cell preparations from 18 patients with RS, 6 with AS, and 22 unaffected subjects were studied toward Shigella flexneri, Salmonella typhimurium, Yersinia enterocolitica, Klebsiella pneumoniae, and Chlamydia trachomatis. Although RS, AS, and HLA-B27-positive normal subjects had generally higher mean responses than HLA-B27-negative controls, no significant differences were demonstrated. Using a chromium release assay, the cytotoxicity of an HLA-B27 antiserum was not altered by preincubation of lymphocytes with these organisms for several individual subjects in each study group.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Paronen I (1948) Reiter's disease. A study of 344 cases observed in Finland. Acta Med Scand (Suppl) 212:1–114

    Google Scholar 

  2. Noer HR (1966) An “experimental” epidemic of Reiter's syndrome. JAMA 198:693–698

    Google Scholar 

  3. Sairanen E, Tiilikainen A (1975) HL-A27 in Reiter's disease following shigellosis. Scand J Rheumatol 4 (Suppl 8):30–11 (Abstr)

    Google Scholar 

  4. Good AE, Schultz JS (1977) Reiter's syndrome following Shigella flexneri 2a. A sequel to traveler's diarrhea — report of a case with hepatitis. Arthritis Rheum 20:100–104

    Google Scholar 

  5. Vartiainen J, Hurri L (1964) Arthritis due to Salmonella typhimurium. Report of 12 cases of migratory arthritis in association with Salmonella typhimurium infection. Acta Med Scand 175:771–776

    Google Scholar 

  6. Friis J, Svejgaard A (1974) Salmonella arthritis and HL-A27. Lancet 1:1350

    Google Scholar 

  7. Leino R, Kalliomaki JL (1964) Yersinosis as an internal disease. Am J Med 81:458–461

    Google Scholar 

  8. Aho K, Ahvonen P, Lassus A, Siever K, Tiilikainen A (1974) HL-A27 in reactive arthritis. A study of Yersinia arthritis and Reiter's disease. Arthritis Rheum 17:521–526

    Google Scholar 

  9. Laitinen O, Leirisallo M, Skylr G (1977) Relationship between HLA-B27 and clinical features in patients with Yersinia arthritis. Arthritis Rheum 20:1121–1123

    Google Scholar 

  10. Keat AC, Maini RN, Nkwazi GC, Pegrum GD, Ridgway G, Scott JT (1978) Role of chlamydia trachomatis and HLA-B27 in sexually acquired reactive arthritis. Br Med J 1:605–607

    Google Scholar 

  11. Kousa M, Saikku P, Richmond S, Lassus A (1978) Frequent association of Chlamydial infection with Reiter's syndrome. Sex Transm Dis 5:57–61

    Google Scholar 

  12. Ebringer RW, Cawdell DR, Cowling P, Ebringer A (1978) Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis 37:146–151

    Google Scholar 

  13. Eastmond CJ, Willshaw HE, Burgess SEP, Shinebaum R, Cooke EM, Wright V (1980) Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease. Ann Rheum Dis 39:118–123

    Google Scholar 

  14. Warren RE, Brewerton DA (1980) Faecal carriage of Klebsiella by patients with ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis 39:37–44

    Google Scholar 

  15. Seager K, Bashir HV, Geczy AF, Edmonds J, de Vere-Tyndall A (1979) Evidence for a specific B 27 — associated cell surface marker on lymphocytes of patients with ankylosing spondylitis. Nature 277:68–70

    Google Scholar 

  16. Geczy AF, Alexander K, Bashir HV, Edmonds J (1980) A factor(s) in Klebsiella culture filtrates specifically modifies an HLA-B27 associated cell-surface component. Nature 283: 782–784

    Google Scholar 

  17. Edmonds J, Macauley D, Tyndall A, Liew M, Alexander K, Geczy AF, Bashir HV (1981) Lymphocytotoxicity of anti-Klebsiella antisera in ankylosing spondylitis and related arthropathies-patient and family studies. Arthritis Rheum 24:1–7

    Google Scholar 

  18. Gofton JP (1966) Report from the subcommittee on diagnostic criteria for ankylosing spondylitis. In: Bennett PH, Wood PNH (eds) Population studies of the rheumatic diseases. Excerpta Medica, Amsterdam

    Google Scholar 

  19. Kellgren JH (1962) Diagnostic criteria for population studies. Bull Rheum Dis 13:291–292

    Google Scholar 

  20. Ford DK (1970) Reiter's syndrome. Bull Rheum Dis 20: 588–591

    Google Scholar 

  21. Amos DB, Bashir H, Boyle W, MacQueen M, Tiilkainen A (1969) A simple microcytotoxicity test. Transplantation 7: 220–223

    Google Scholar 

  22. Bowie WR (1978) Etiology and treatment of nongonococal urethritis. Sex Transm Dis 5:27–33

    Google Scholar 

  23. Amor B, Kohan J, Solnik C (1977) Antibodies against Chlamydia in Reiter's syndrome. Proceedings of the XIV International Congress of Rheumatology, San Francisco, CA, USA, 1104 (Abstr)

  24. Smith DE, James PG, Schacter J, Engleman EP, Meyer KF (1973) Experimental bedsonial arthritis. Arthritis Rheum 16:21–29

    Google Scholar 

  25. Arnett FC, Hochberg MC, Bias WB (1977) Cross-reactive HLA antigens in B27-negative Reiter's syndrome and sacroiliitis. Johns Hopkins Med J 141:193–197

    Google Scholar 

  26. Schwartz B, Luehrman LK, Rodey GE (1978) A public antigenic determinant on a family of HLA-B molecules. A basis for cross-reactivity and possible link with disease predisposition. J Clin Invest 64:938–947

    Google Scholar 

  27. McLain DA, Luehrman LK, Rodey GE, Schwartz BD (1980) An HLA public antigen is more common than HLA-B27 in patients with ankylosing spondylitis. Arthritis Rheum 23:718 (Abstr)

    Google Scholar 

  28. Welsh J, Avakian H. Cowling P, Ebringer A, Wooley P, Panayi G, Ebringer R (1980) Ankylosing Spondylitis HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera. Br J Exp Pathol 61:85–96

    Google Scholar 

  29. Esconilla F, Alepa PF, Reefe W (1970) Impaired lymphocyte responses in ankylosing spondylitis. Arthritis Rheum 13:314 (Abstr)

    Google Scholar 

  30. Sturrock RD, Froebel K, MacSween RNM, Dick WC (1975) Evidence of impaired cell mediated immunity in the seronegative arthritides. Ann Rheum Dis 34:203 (Abstr)

    Google Scholar 

  31. Fan PT, Clements PJ, Yu DTY, Opelz G, Bluestone R (1977) Lymphocyte abnormalities in ankylosing spondylitis. Ann Rheum Dis 36:471–473

    Google Scholar 

  32. Ford DK (1981) The specificity of synovial lymphocyte responses to microbial antigens. Arthritis Rheum 24:563 (Abstr)

    Google Scholar 

  33. Burmester GR, Bona AD, Yu DTY, Kunkel HG, Steiner G, Winchester RJ (1981) Characterization of the surface phenotype of T cells and lining cells found in the synovial tissues of patients with rheumatoid arthritis. Arthritis Rheum (in press)

Download references

Author information

Authors and Affiliations

  1. Rheumatology Division and Immunogenetics Laboratory, The Johns Hopkins University School of Medicine and Hospital and the Good Samaritan Hospital, Baltimore, Maryland, USA

    R. W. Enlow, W. B. Bias, R. Bluestone & F. C. Arnett

  2. The Wadsworth Veteran's Administration Hospital, Los Angeles, California, USA

    R. W. Enlow, W. B. Bias, R. Bluestone & F. C. Arnett

Authors
  1. R. W. Enlow
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. B. Bias
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Bluestone
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. C. Arnett
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Enlow, R.W., Bias, W.B., Bluestone, R. et al. Human lymphocyte response to selected infectious agents in Reiter's syndrome and ankylosing spondylitis. Rheumatol Int 1, 171–175 (1982). https://doi.org/10.1007/BF00541172

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00541172

Key words

Search

Navigation