Summary
In 46 persons among 119 workers at a foundry producing manganese alloy, manganese levels of over 20 µg% were found in the blood without marked objective symptoms of manganese poisoning. Comparison with a control group showed differences in magnesium and calcium levels, AlAT, AspAT, LDH, LAP activities, albumin, α 1- and Β-globulin, bilirubin, cholesterol levels in serum and hemoglobin and reduced glutathion concentrations in red cells. The group was checked up within one to two years after exposure stopped. Gradually manganese levels became normal, as well as practically all biochemical parameters which had revealed marked deviations from the norm at the time of exposure. Subjective and objective disturbances, however, showed a much slighter tendency to regress. The results of the investigations prove the wisdom of rotating workers in jobs where they are exposed to manganese, and justify extension of medical prophylaxis.
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References
Abd el Naby, S., Hassanein, H.: Neuropsychiatric manifestations of chronic manganese poisoning. J. Neurol. Neurosurg. Psychiat. 28, 282 (1965).
Basinski, V.: Cit. after M. Büchner, and H. Ch. Gabsch: Moderne chemische Methoden in der Klinik. Leipzig: VEB Georg Thieme 1961.
Bertichamps, A. J., Miller, S. T., Cotzias, G. C.: Independence of routes excreting manganese. Amer. J. Physiol. 211, 217 (1966).
Bodansky, A.: Phosphatase studies. Determination of serum phosphatase. Factors influencing accuracy of determination. J. biol. Chem. 101, 93 (1933).
Chubutija, W. A.: Hematological changes in workers employed in contact with manganese [Russ.]. Gig. Tr. prof. Zabol. 8, 39 (1964).
Clemente, C. D.: Regeneration in the vertebrate central nervous system. Int. Rev. Neurobiol. 6, 257 (1964).
Colombo, J. P., Richterich, R.: Zur Bestimmung des CÄruloplasmins im Plasma. Schweiz. med. Wschr. 94, 715 (1964).
Cotzias, G. C.: Manganese in health and disease. Physiol. Rev. 38, 503 (1958).
—: Manganese. In: Mineral metabolism. vol. 2B, chapt. 33. New York: Acad. Press Inc. 1962.
—, van Woert, M. H.: Manganese poisoning—new insights. Rev. Neuro-psiquiat. 27, 392 (1964).
Dubach, U. C.: Un test fermentaire simple pour diagnostique l'infactus du myocarde. Triangle (Fr.) 3, 234 (1950).
Fiske, C. H., Subbarow, Y.: In: J. Homolka, Biochemical diagnostics [Pol.]. Warsaw: PZWL 1958.
Gracjanskaja, L. N.: Chronic industrial manganese poisoning. Some new insights [Russ.]. Gig. Tr. prof. Zabol. 1, 30 (1957).
Jendrassik, L., Gróf, P.: Cit. after J. Homolka, Biochemical diagnostics [Pol.]. Warsaw: PZWL 1958.
Jonderko, G.: Investigations on pathogenetic mechanisms of chronic manganese poisoning [Pol.]. Katowice: Slaska Akademia Medyczna 1970.
Jonderko, G., Kujawska, A., Langauer-Lewowicka, H.: Studies of early symptoms of the toxic influence of manganese [Pol.]. Med. Pracy 22, 1 (1971).
—, Smolarz, W., Sybirska, H.: Early form of chronic manganese poisoning [Pol.]. Med. Pracy 15, 177 (1964).
—, Szczurek, Z.: Pathomorphologische Untersuchungen innerer Organe bei experimenteller Manganvergiftung. Int.Arch. Gewerbepath. Gewerbehyg. 23, 106 (1967).
Kovacs, G. S., Tarnoky, K. E.: A simple and rapid method for the simultaneous determination of calcium and magnesum from the same sample of blood serum. J. clin. Path. 13, 160 (1960).
Laurell, C. B.: Cit. after E. Biró, and J. Fedorcsák, Handbuch zu dem Photometer Unifot. Budapest: Optische Werke 1963.
Lutier, F.: Le manganisme dans l'industrie des piles électriques. Presse méd. 71, 661 (1963).
Mac Donald, R. F., Simpson, J. R.: Cit. after P. Bálint, Klinische Laboratoriumsdiagnostik, Bd. I. Berlin: VEB Verlag Volk 1963.
Murphy, G., Abbona, J. M.: Intoxicacion cronica por manganeso. Pren. méd. argent. 46, 845 (1959).
Papavasiliou, P. S., Miller, S. T., Cotzias, G. C.: Role of liver in regulating distribution and excretion of manganese. Amer. J. Physiol. 211, 211 (1966).
Paterni, L.: Emopatie da metalli. Fol. med. (Napoli) 37, 994 (1954).
Pekárek, V., Ponča, E., Jizera, Z.: Working environment and health condition of workers employed in the production of permaganate [Czech.]. Pracov. Lék. 9, 104 (1957).
Penalver, R.: Diagnosis and treatment of manganese intoxication. Arch. industr. Health 16, 64 (1957).
Rodier, J.: Le manganisme au Maroc. méd. 37, 429 (1958).
Ryżkowa, M. N.: Problems of the clinical picture and pathophysiology of chronic manganese poisoning [Russ.]. Gig. Tr. prof. Zabol. 3/5, 37 (1959).
Szobor, A.: Contribution à la question du manganisme. Psychiat. et Neurol. (Basel) 133, 221 (1957).
Tanaka, S., Lieben, J.: Manganese poisoning and exposure in Pennsylvania. Arch. environm. HIth 19, 674 (1969).
Tulczyński, M.: Clinical laboratory diagnostic methods [Pol.]. Warsaw: PZWL 1962.
Turner, T., Ealis, L.: Quantitative determination of cholesterol in serum with p-toluenesulfonic acid. Scand. J. clin. Lab. Invest. 9, 210 (1957).
Uiberall, E., Politoff, A., Maturana, V.: Aspectos neurologicos de la intoxicacion manganesica. Rev. Neuro-psiquit. 27, 376 (1964).
Vincent, D., Segonzac, G.: Cit. after M. Tulczyński (1962).
Voigt, G. E., Saldeen, T.: über den Schutzeffekt des Zinks gegenüber Mangansulfatoder Kohlenstofftetrachlorid-induzierenden LeberschÄden. Frankfurt. Z. Path. 74, 572 (1965).
Wróblewski, F., Cabaud, Ph.: Colorimetric measurement of serum glutamic-peruvic transaminase. Amer. J. clin. Path. 27, 235 (1957).
Wynter, J. E.: The prevention of manganese poisoning. Industr. Med. Surg. 31, 308 (1962).
Zawadzka, E., Braszczyńska, Z., Machnik, D., Szyja, J.: Investigations on air contamination with noxious substances in a manganese alloy foundry [Pol.]. Instytut Med. Pracy w PrzemylŚe Weglowym i Hutniczym, Zabrze, 1968.
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Jonderko, G., Kujawska, A. & Langauer-Lewowicka, H. Problems of chronic manganese poisoning on the basis of investigations of workers at a manganese alloy foundry. Int. Arch. Arbeitsmed 28, 250–264 (1971). https://doi.org/10.1007/BF00539137
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DOI: https://doi.org/10.1007/BF00539137