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The antagonism between reserpine and some antiparkinson drugs in electroseizure

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Summary

The effects of amphetamine, metamphetamine, propylhexedrine, biperiden and atropine were studied in experiments on electroseizure threshold in rats. In high doses these drugs lowered the threshold of electroseizures and antagonized the threshold lowering produced by reserpine, with the exception of atropine, which enhanced the action of reserpine. Low doses of the drugs and combinations of low doses of metamphetamine, propylhexedrine and biperiden did not influence electroseizure threshold, but inhibited the action of reserpine. The effect of phenytoin on the threshold lowered by reserpine was enhanced by low doses of metamphetamine, propylhexedrine and biperiden. Tetrabenazine caused threshold lowering which was antagonized by metamphetamine, propylhexedrine, biperiden and atropine. Pretreatment with α-methyl-p-tyrosine, but not with diethyldithiocarbaminate abolished the effect of high doses of metamphetamine or propylhexedrine on the electroseizure threshold. Inhibition of the formation of DOPA or noradrenaline did not influence the action of reserpine or the antagonism between reserpine and the drugs of the amphetamine group. After a repeated injection of metamphetamine tachyphylaxis developed.

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  1. Pharmakologisches Institut der Universität des Saarlandes Homburg (Saar), Germany

    I. Jurna & Brigitte Regélhy

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  1. I. Jurna
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  2. Brigitte Regélhy
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This work is dedicated to Prof. v. Brücke on the occasion of his 60th birthday.

Supported by a grant of the Deutsche Forschungsgemeinschaft.

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Jurna, I., Regélhy, B. The antagonism between reserpine and some antiparkinson drugs in electroseizure. Naunyn-Schmiedebergs Arch. Pharmak. u. Exp. Path. 259, 442–459 (1968). https://doi.org/10.1007/BF00538559

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  • DOI: https://doi.org/10.1007/BF00538559

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