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Zur Immunsuppression durch Leukämieviren

Immunsuppressive effects of leukemia viruses. Studies with Rauscher virus in mice resistant to leukemia

Untersuchungen mit dem Rauscher-Virus an einem Leukämie-Resistenten Mäusestamm

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Summary

After infection with the Rauscher-virus, BALB/C-mice develop typical Rauscher-leukemia with viremia and splenic enlargement of more than 2 g. From the 7th day after infection immunization with heterologous erythrocytes reveals a marked immunesuppression.

C 57/Bl/7-mice are resistant to leukemia. After infecting, them with virus there is only a mild transitory viremia with slight splenic enlargement. Immune suppression is also demonstrable during the viremia phase.

Immune suppression by Rauscher-virus seems to depend upon unknown cellular damage due to the virus. It is not associated with the development of leukemia.

Zusammenfassung

Inzuchtmäuse des Stammes BALB/C entwickeln nach Infektion mit dem Rauscher-Virus die typische Rauscher-Leukämie mit Virämie und Milztumoren bis weit über 2 g. Nach Immunisierung mit heterologen Erythrocyten findet sich ab dem 7. Tag nach der Infektion eine ausgeprägte Immunsuppression.

Der Stamm C 57/Bl/6 ist leukämie-resistent. Nach der Virusinfektion tritt lediglich eine vorübergehende schwache Virämie mit einer geringen Milzvergrößerung (maximal 0,4 g) auf. Auch hier läßt sich zum Zeitpunkt der Virämie eine Immunsuppression nachweisen.

Die Immunsuppression durch das Rauscher-Virus scheint daher von einer unbekannten virusbedingten Zellschädigung abhängig zu sein; sie ist nicht an das Auftreten einer Leukämie gebunden.

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Authors and Affiliations

  1. Institut für experimentelle Pathologie der Farbenfabriken Bayer AG, Wuppertal-Elberfeld

    H. J. Seidel & K. Lauenstein

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  1. H. J. Seidel
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  2. K. Lauenstein
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Seidel, H.J., Lauenstein, K. Zur Immunsuppression durch Leukämieviren. Z Krebs-forsch 72, 219–225 (1969). https://doi.org/10.1007/BF00524336

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