Skip to main content
SpringerLink
Log in

Genetic studies of human erythrocyte inosine triphosphatase

  • Published:
Biochemical Genetics Aims and scope Submit manuscript

Abstract

The high concentrations of inosine triphosphate in human erythrocytes of some subjects has been related to a deficiency in intracellular inosine triphosphatase. Evidence has been presented for genetic transmission of this enzyme and for the existence of a homozygous-heterozygous relationship. Pedigree studies of individuals with erythrocyte ITPase deficiency suggest a Mendelian autosomal trait.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Blecher, M. (1964). Determination of inorganic orthophosphate in the presence of adenosine triphosphate; A critique. Anal. Biochem. 7 383.

    Google Scholar 

  • Fiske, C. H., and SubbaRow, Y. (1925). The colorimetric determination of phosphorus. J. Biol. Chem. 66 375.

    Google Scholar 

  • Liakopoulou, A., and Alivasatos, S. G. A. (1964). Distribution of nucleoside triphosphatases in human erythrocytes. Biochem. Biophys. Acta 89 158.

    Google Scholar 

  • Vanderheiden, B. S. (1964). Separation, identification, and quantitative determination of P32-labeled phosphate esters from erythrocytes. Anal. Biochem. 8 1.

    Google Scholar 

  • Vanderheiden, B. S. (1965). Inosine triphosphate in human erythrocytes: A genetic trait. Proc. 10th Congr. Intern. Soc. Blood Transf. Stockholm, 1964, p. 540.

  • Vanderheiden, B. S. (1967). Phosphate esters of human erythrocytes: synthesis of ITP-14C from inosine-8-14C. Nature 216 1036.

    Google Scholar 

  • Vanderheiden, B. S., and Boszormenyi-Nagy, I. (1965). Preparation of 32P-labeled nucleotides. Anal. Biochem. 13 496.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eastern Pennsylvania Psychiatric Institute, 19129, Philadelphia, Pennsylvania

    Bernardo S. Vanderheiden

Authors
  1. Bernardo S. Vanderheiden
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This investigation was partly supported by PHS Research Grant No. Am-11116 from the National Institute of Arthritis and Metabolic Disorders.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vanderheiden, B.S. Genetic studies of human erythrocyte inosine triphosphatase. Biochem Genet 3, 289–297 (1969). https://doi.org/10.1007/BF00521144

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00521144

Keywords

Search

Navigation