Skip to main content
Log in

The tissue dynamics of heart morphogenesis

I. The phenomena of cell death B. Topography

  • Published:
Zeitschrift für Anatomie und Entwicklungsgeschichte Aims and scope Submit manuscript

Summary

Zones of cell death in the chick embryo heart were demonstrated by a study of cardiac morphogenesis on the light microscopical level.

Between the 2nd and 20th day of incubation 31 foci of cell degeneration were found.

The greatest number of dying cells occured on the 4th day of incubation and was located in the heart bulbus and bulbar cushions. The largest number of different degenerative foci were present on the 6th incubation day. Starting on the 10th day of incubation, both the number of degeneration zones and their population of dying cells decreased.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bessis, M.: Studies on cell agony and cell death: an attempt of classification. In: Ciba Foundation Symposium on Cellular Injury (eds. A. V. S. de Reuck and J. Knight), p. 287–315. London: Churchill 1964.

    Google Scholar 

  • Biggers, J. D.: The death of cells in normal multicellular organisms. In: Ciba Foundation Symposium on Cellular injury (eds. A. V. S. de Reuck and J. Knight), p. 329–347. London: Churchill 1964.

    Google Scholar 

  • David, H.: Sterben und Tod der Zelle. Mber. dtsch. Akad. Wiss. 7, 452–463 (1965).

    Google Scholar 

  • Dbalý, J.: The development of branching of the coronary arteries in the chick. Čs. Morfol. 12, 401–414 (1964).

    Google Scholar 

  • Ernst, M.: Über Untergang von Zellen während der normalen Entwicklung bei Wirbeltieren. Z. Anat. Entwickl.-Gesch. 79, 228–262 (1926).

    Google Scholar 

  • Forsberg, J.-G., Källén, B.: Cell death during embryogenesis. Rev. roum. Embryol. Cytol., Sér. Embryol. 5, 91–102 (1968).

    Google Scholar 

  • Glücksmann, A.: Cell deaths in normal vertebrate ontogeny. Biol. Rev. 25, 59–86 (1951).

    Google Scholar 

  • Goerttler, Kl.: Die Stoffwechseltopographie des embryonalen Hühnerherzens und ihre Bedeutung für die Entstehung angeborener Herzfehler. Verh. dtsch. Ges. Path. 40, 181–185 (1956).

    Google Scholar 

  • Goerttler, Kl.: Wachstum als Entwicklung zum Tode. Hippokrates (Stuttg.) 39, 597–605 (1968).

    Google Scholar 

  • Grohmann, D.: Mitotische Wachstumsintensität des embryonalen und fetalen Hühnchenherzens und ihre Bedeutung für die Entstehung von Herzmißbildungen. Z. Zellforsch. 55, 104–122 (1961).

    Google Scholar 

  • Hecht, A.: Zur Pathohistochemie enzymatischer Befunde als Ausdruck reversibler und irreversibler Störungen des Zellmetabolismus und über ihre Beziehungen zum örtlichen Zelltod. Dtsch. Gesundh.-Wes. 23, 77–82 (1968).

    Google Scholar 

  • Illies, A.: La topographie et la dynamique des zones nécrotiques normales chez l'embryon humain. Rev. roum. Embryol. Cytol., Sér. Embryol. 4, 57–85 (1967).

    Google Scholar 

  • Källén, B.: Degeneration and regeneration in the vertebrate central nervous system during embryogenesis. Progr. Brain Res. 14, 77–96 (1965).

    Google Scholar 

  • Krstić, R., Pexieder, T.: Elektronenmikroskopische Darstellung des Zellunterganges in den Herzbulbuswülsten des Hühnerembryos. Abstract. Verh. Anat. Schweiz. Hochschulen, Bern, 1971. Acta anat. (Basel) 82, 470 (1972).

    Google Scholar 

  • Manasek, F. J.: Myocardial cell death in the embryonic chick ventricle. J. Embryol. exp. Morph. 21, 271–284 (1969).

    Google Scholar 

  • Menkes, B., Alexandru, C., Pavkov, A., Mircova, O.: Researches on the formation and the elastic structure of the aortopulmonary septum in the chick embryo. Rev. roum. Embryol. Cytol., Sér. Embryol. 1, 69–78 (1965).

    Google Scholar 

  • Menkes, B., Deleanu, M., Illies, A.: Comparative study of some areas of physiological necrosis at the embryo of man, some laboratory animals and fowl. Rev. roum. Embryol. Cytol., Sér. Embryol. 2, 161–172 (1965).

    Google Scholar 

  • Menkes, B., Litvac, B., Illies, A.: Spontaneous and induced cell degenerescence in relation to teratogenesis. Rev. roum. Embryol. Cytol., Sér. Embryol. 1, 1–60 (1964).

    Google Scholar 

  • Menkes, B., Pavkov, A.: Zellnekrosen in spontanen Augenmißbildungen des Hühnerembryos. Rev. roum. Embryol. Cytol., Sér. Embryol. 4, 47–49 (1967).

    Google Scholar 

  • Menkes, B., Sandor, S., Illies, A.: Cell death in teratogenesis. In: Advances in teratogenesis (ed. D. H. M. Woollam), vol. 4, p. 170–215. Oxford: Logos Press 1970.

    Google Scholar 

  • Patten, B. M.: The formation of the cardiac loop in the chick. Amer. J. Anat. 30, 373–397 (1922).

    Google Scholar 

  • Pexieder, T.: Blood pressure in the third and fourth aortic arch and morphogenetic influence of laminar blood streams in the development of the vascular system of the chick embryo. Folia morph. (Praha) 17, 273–290 (1969).

    Google Scholar 

  • Pexieder, T.: Beobachtungen über den lokalen Zelltod während der Herzbulbusseptierung des Hühnerembryos. Verh. anat. Ges. Zagreb, 1971. Anat. Anz. 131, Erg.-H., 279–286 (1972a).

    Google Scholar 

  • Pexieder, T.: Über die Wirkung der Haemodynamik auf den Zelluntergang in den Herzbulbuswülsten des Hühnerembryos. Verh. Anat. Schweiz. Hochschulen, Bern, 1971. Abstract. Acta anat. (Basel) 82, 459–460 (1972b).

    Google Scholar 

  • Pexieder, T.: The tissue dynamics of heart morphogenesis. I. The cell death phenomenon. A. Identification and morphology. Z. Anat. Entwickl.-Gesch. 137, 270–284 (1972c).

    Google Scholar 

  • Politzer, G.: Über einen menschlichen Embryo mit 18 Ursegmentpaaren. Z. Anat. Entwickl.-Gesch. 87, 674–727 (1928).

    Google Scholar 

  • Rao, S. N., Wynn-Williams, A.: Comparison of post-mortem and ischaemic changes in the absorptive cells of the jejunal mucosa in mice. Proc. Univ. Otago med. Sch. 47, 89–90 (1969).

    Google Scholar 

  • Rickenbacher, J.: Versuche mit Contergan am Hühnerkeimling. Dtsch. med. Wschr. 88, 2252–2260 (1963).

    Google Scholar 

  • Rychter, Z.: The vascular system of the chick embryo. III. On the problem of septation of the heart bulb and trunc in chick embryos. Čs. Morfol. 7, 1–20 (1959).

    Google Scholar 

  • Rychter, Z., Lemež, L.: Experimentelle Untersuchung über die Entstehung sowie die Lage und Größe von Kammerseptumdefekten am Herzen von Hühnerembryonen. Anat. Anz. 104, Erg.-H., 97–102 (1957).

    Google Scholar 

  • Rychter, Z., Lemež, L.: Experimenteller Beitrag zur Entstehung der Transpositionen von Aorta in die rechte Herzkammer der Hühnerembryonen. Anat. Anz. 105, Erg.-H., 310–315 (1959).

    Google Scholar 

  • Rychter, Z., Lemež, L.: The vascular system of the chick embryo. VII. The theory of the teratogenic significance of the heart loop and aortic arches local damage. Čs. Morfol. 8, 417–434 (1960).

    Google Scholar 

  • Rychter, Z., Lemež, L.: Markierung morphogenetischer Bewegungen während der Truncusscheidewandbildung des Herzens beim Hühnerembryo. Zusammenfassung der Vorträge. VIII. Internationaler Anatomenkongreß. Wiesbaden (1965).

  • Rychter, Z., Ošťádal, B.: Periodisation of the blood supply development of the myocardium in chick embryo. Abstract. Physiol. bohemoslov. 17, 485 (1968).

    Google Scholar 

  • Sandor, S.: The influence of ethylalcohol on the developing chick embryo. Rev. roum. Embryol. Cytol., Sér. Embryol. 5, 167–171 (1968).

    Google Scholar 

  • Saunders, J. W., jr.: Death in embryonic systems. Science 154, 604–612 (1966).

    Google Scholar 

  • Seichert, V.: Study of the tissue and organ anlage shifts by the method of plastic linear marking. Folia morph. (Praha) 13, 228–238 (1965).

    Google Scholar 

  • Stalsberg, H.: Mechanism of dextral looping of the embryonic heart. Amer. J. Cardiol. 25, 265–271 (1970).

    Google Scholar 

  • Töndury, G.: Embryopathien. Berlin-Göttingen-Heidelberg: Springer 1962.

    Google Scholar 

  • Whitten, J. M.: Cell death during early morphogenesis. Paralleles between insect limb and vertebrate limb development. Science 163, 1456–1457 (1969).

    Google Scholar 

  • Zwilling, E.: Controlled degeneration during development. In: Ciba Foundation Symposium on Cellular Injury (eds. A. V. S. de Reuck, J. Knight), p. 352–361. London: Churchill 1964.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This work was in part supported by grants no. B70-12X-579 from the Swedish Medical Research Council and no. 108-K69 from the Swedish Cancer Society.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pexieder, T. The tissue dynamics of heart morphogenesis. Z. Anat. Entwickl. Gesch. 138, 241–253 (1972). https://doi.org/10.1007/BF00520705

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00520705

Key words

Navigation