Summary
The neuromeric mes-rhombencephalic boundary runs between the oculomotor and trochlear nuclei. During morphogenesis the m 2-segment is reduced to a cellfree mantle demarcating a morphological mes-rhombencephalic border. The floor plate and glycogen-containing raphe extend rostralwards to terminate at the level of the m 2-segment ventromedially.
The isthmic migration commences within the dorsal and dorsolateral rhombencephalic cell columns caudal to the emergence of the trochlear nerve. The neuroblasts migrate radially out from the synthetic zone of the neural epithelium into the mantle constituting the isthmic migration. The latter migrate longitudinally “en masse” rostralwards into the mantle below the optic lobe. The m 2-segment can, however, be identified as a morphological border between the mesencephalic and isthmic (rhombencephalic) mantles throughout the early embryogenesis.
The isthmic migration subdivides into a tectal and a tegmental nuclear group. Both groups contribute to the formation of the isthmic nuclei. The caudal portion of the mesencephalic tectal mantle contributes to a mesencephalic isthmic nucleus: Nucleus isthmi principalis mesencephali (magnocellularis).
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References
Adelmann, H. B.: The development of neural folds and cranial ganglia of the rat. J. comp. Neurol. 39, 19–171 (1925)
Ahlborn, F.: Untersuchungen über das Gehirn der Petromyconten. Z. wiss. Zool. 39, 191–294 (1883)
Ariens Kappers, C. U., Huber, G. C., Crosby, E. C.: The comparative anatomy of the nervous system of vertebrates, including man. New York: Hafner Publishing Co. 1960
Bartelmez, G. W., Evans, H. M.: The development of the human embryo during the period of somite formation including embryos with 2 to 16 pairs of somites. Contr. Embryol. Carneg. Instr. 17, 1–67 (1926)
Bellonci, J.: Über die centrale Endigung des Nervus opticus bei den Vertebraten. Z. wiss. Zool. 47, 1–46 (1888)
Bengmark, S., Hugosson, R., Källén, B.: Studien über Kernanlagen im Mesencephalon sowie im Rostralteil des Rhombencephalon von Mus musculus. Z. Anat. Entwickl.-Gesch. 117, 73–91 (1953)
Bergquist, H., Källén, B.: Studies on the topography of the migration areas in the vertebrates brain. Acta anat. (Basel) 17, 353–369 (1953)
Bergquist, H., Källén, B.: Notes on the early histogenesis and morphogenesis of the central nervous system in vertebrates. J. comp. Neurol. 100, 627–660 (1954)
Bradley, O. C.: Neuromeres of the rhombencephalon of the pig. Rev. Neurol. Psychiat. (Paris) 2, 625–635 (1904)
Braun-Jacobson, A.: Development of mesencephalic nuclei in the chick embryo (Gallus domesticus). Z. Anat. Entwickl.-Gesch. 135, 317–336 (1972)
Brodal, A., Kristiansen, K., Jansen, J.: Experimental demonstration of a pontine homologue in brids. J. comp. Neurol. 92, 23–69 (1950)
Broman, I.: Beschreibung eines menschlichen Embryos von beinahe 3 mm Länge mit spezieller Bemerkung über die bei demselben befindlichen Hirnfalten. Morph. Arb. 5, 169–205 (1896)
Craigie, E. H.: Observations on the brain of the humming bird (Chrysolampis mosquitus Linn. and Chlorostilbon caribaeus Lawr.) J. comp. Neurol. 45, 377–392 (1928)
Essick, C. R.: The development of the nuclei pontis and the nucleus arcuatus in man. Amer. J. Anat. 13, 25–54 (1912)
Hamburger, V., Hamilton, H. L.: A series of normal stages in the development of chick embryo. J. Morph. 88, 49–92 (1951)
Hamburger, V., Levi-Montalcini, R.: Some aspects of neuroembryology In: Genetic neurology (P. Weiss, ed.). Chicago: Chicago Univ. Press 1950
Harkmark, W.: Cell migration from the rhombic lip to the inferior olive, the nucleus raphe and the pons. A morphological and experimental investigation on chick embryos. J. comp. Neurol. 100, 115–209 (1954a)
Harkmark, W.: The rhombic lip and its derivatives in relation to the theory of neurobiotaxis. In: Aspects of cerebellar anatomy (eds., J. Jansen and A. Brodal), p. 264–284. Oslo: Grundt Tanum 1954b
Harkmark, W.: Personal communications (1960)
Hill, C.: Developmental history of primary segments of the vertebrate head. Zool. Jb. Abt. Anat. u. Ontog. 13, 393–446 (1900)
Hugosson, R.: Morphologic and experimental studies on the development and significance of the rhombencephalic longitudinal cell columns. (Thesis). Lund, Sweden: Hakon Ohlssons boktryckeri 1957
Joustra, N.: Over de homologie van het ganglon isthmi. Psychiat. neurol. Bl. (Amst.) 22, 361–379 (1918)
Jungherr, E.: Certain nuclear groups of the avian mesencephalon. J. comp. Neurol. 82, 55–73 (1945)
Keyser, A.: The development of the diencephalon of the Chinese hamster. Acta anat. (Basel), Suppl 59-1 ad 83 (1972)
Kingsbury, B. F.: The fundamental plan of the vertebrate brain. J. comp. Neurol. 34, 461–492 (1922)
Kupffer, C. v.: Die Morphogenesis des Centralnervensystems. In: Handbuch der vergleichenden und experimentellen Entwicklungslehre der Wirbeltiere (Hrsg. O. Hertwig), Bd. 2, Teil 3. Jena: Gustav Fischer 1906
Larsell, O.: The nucleus isthmi of the frog. J. comp. Neurol. 36, 309–322 (1924)
Le Gros Clark, W.: The medial geniculate body and the ganglion isthmi. J. Anat. (Lond.) 67, 536–545 (1933)
Palmgren, A.: Embryological and morphological studies on the midbrain and cerebellum of vertebrates. Acta zool. (Stockh.) 2, 1–94 (1921)
Rendahl, H.: Embryologische und Morphologische Studien über das Zwischenhirn beim Huhn. Acta zool. (Stockh.) 5, 241–344 (1924)
Rüdeberg, S-I. Morphogenetic studies on the cerebellar nuclei and their homologization in different vertebrates including man. (Thesis). Lund, Sweden: Hakon Ohlssons boktryckeri 1961
Schumacher, O.: Beiträge zur Entwicklungsgeschichte des Vertebratengehirns. IV. Die Entwicklungsgeschichte des Kiebitzgehirns. Z. Anat. Entwickl.-Gesch. 87, 139–251 (1928)
Sundberg, C.: Das Glycogen in menschlichen Embryonen von 15, 27 und 40 mm. Z. Anat. Entwickl.-Gesch. 73, 168–246 (1924)
Tienhoven, A., Juhasz, L. P.: The chicken telencephalon, diencephalon and mesencephalon in stereotaxic coordinates. J. comp. Neurol. 118, 185–97 (1962)
Vaage, S.: A study of the cell migrations in mesencephalon and mesencephalon in chick embryos by autoradiography. Rep. Fourth Scand. Congr. Cell Res. (1965)
Vaage, S.: Segmentation of the primitive neural tube in chick embryos. Ergebn. Anat. Entwickl.-Gesch. 41, 1–88 (1969)
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Vaage, S. The histogenesis of the isthmic nuclei in chick embryos (Gallus domesticus). Z. Anat. Entwickl. Gesch. 142, 283–314 (1973). https://doi.org/10.1007/BF00519134
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DOI: https://doi.org/10.1007/BF00519134