Summary
Histamine has a dual action on the isolated perfused ear preparation of the rabbit. The amine induced a dose-dependent rise in perfusion pressure when the preparation was perfused with Krebs' solution. This pressor response was reversed to a depressor effect when mepyramine was added to the perfusion fluid. This depressor effect of the amine was also dose-related. Metiamide competitively inhibited the depressor effect of histamine. Prior treatment of the ear vessels with metiamide alone caused an increase in histamine-induced perfusion pressure.
From these results it was concluded that the predominant pressor effect of histamine on the vascular bed of the rabbit ear is mediated through the H1-receptors and the depressor effect of the amine through histamine H2-receptors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R., Parsons, E. M.: Definition and antagonism of histamine H2-receptors. Nature (Lond.) 236, 385–390 (1972)
Black, J. W., Duncan, W. A. M., Emmet, J. C., Ganellin, C. R., Hesselbo, T., Parsons, M. E., Wyllie, J. H.: Metiamide-An orally active histamine H2-receptor antagonist. Agents and Actions 3, 133–137 (1973)
Bökesoy, T. A., Türker, R. K.: The presence of histamine H2-receptors in rabbit kidney. Arch. int. Pharmacodyn. 209, 144–149 (1974)
Carroll, P. R., Glover, W. E., Latt, N.: Cardiovascular histamine receptors in the rabbit. Aust. J. exp. Biol. Med. Sci., 52, 577–582 (1974)
Day, M. D., Owen, D. A. A.: The interaction between angiotensin and sympathetic vasoconstriction in the isolated artery of the rabbit ear. Brit. J. Pharmac., 34, 499–507 (1968)
De La Lande, I. S., Rand, M. J.: A simple isolated nerve-blood vessel preparation. Aust. J. Exp. Biol. med. Sci. 43, 639–659 (1965)
Ercan, Z. S., Bökesoy, T. A., Türker, R. K.: A study of the histamine H2-receptors in heart muscle and coronary vessels. Europ. J. Pharmacol. 27, 259–262 (1974)
Glover, W. E., Carroll, P. R., Latt, N.: Histamine receptors in human temporal and rabbit ear arteries. In: C. J. Wood and M. A. Simkins (Eds.): International Symposium on histamine H2-receptor antagonists, pp. 169–174. London: Smith Kline & French 1973
Goadby, P., Phillips, E. A.: Some effects of burimamide on the isolated perfused pulmonary circulation of the guinea-pig. Brit. J. Pharmacol. 49, 368–369 (1973)
Okpako, D. T.: The actions of histamine and prostaglandins F2a and E2 on pulmonary vascular resistance of the lung of the guinea-pig. J. Pharm. Pharmacol. 24, 40–46 (1972a)
Okpako, D. T.: A dual action of histamine on guinea-pig lung vessels. Brit. J. Pharmacol. 44, 311–321 (1972b)
Schild, H. O.: pA, a new scale for the measurement of drug antagonism. Brit. J. Pharmacol. 2, 189–206 (1947)
Türker, R. K.: Presence of histamine H2-receptors in the guinea-pig pulmonary vascular bed. Pharmacology 9, 306–311 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ercan, Z.S., Türker, R.K. Histamine receptors in the vasculature of the rabbit ear. Naunyn-Schmiedeberg's Arch. Pharmacol. 291, 23–29 (1975). https://doi.org/10.1007/BF00510818
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00510818