Summary
The effect of noradrenaline on the depolarization-evoked release of 3H-5-hydroxytryptamine was investigated in superfused synaptosomes prepared from rat cortex and hippocampus and prelabelled with the radioactive indoleamine. Noradrenaline reduced in a concentration-dependent way the release of 3H-5-hydroxytryptamine elicited by 15 mM KCl. The inhibition was counteracted by the alpha-adrenoceptor antagonists phentolamine or yohimbine, but not by prazosin. The results indicate that, in rat brain, the inhibition of 5-hydroxytryptamine release by noradrenaline is mediated by adrenoceptors of the alpha2-type localized on the terminal serotonergic fibres.
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Maura, G., Gemignani, A. & Raiteri, M. Noradrenaline inhibits central serotonin release through alpha2-adrenoceptors located on serotonergic nerve terminals. Naunyn-Schmiedeberg's Arch. Pharmacol. 320, 272–274 (1982). https://doi.org/10.1007/BF00510140
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DOI: https://doi.org/10.1007/BF00510140