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Das Hamstermelanom M Mel 1 als Ascitestumor

I. Vergleichende Zusammenstellung der Eigenschaften der verschiedenen Hamster- und Mäusemelanome. Eingehende Beschreibung der Ascitesform

The hamster melanoma M Mel 1 as ascites tumor

I. Comparison of the various melanoma of the Syrian hamster and the mice detailed description of the ascitic melanoma Asc-M Mel 1

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Summary

In the last decennia the experimental research work on melanoma has been given considerable impetus by the frequence of occurence of spontaneous melanoma in hamsters. The comparative studies show great differences the various types of tumor.

Our own studies deal especially with the transformation of the solid spontaneous hamster melanom M Mel 1 in an ascitic form and with its consequent biological behaviour.

The ascites form permits an exact determination of the LD 50 after intraperitoneal and subcutaneous injection. After intraperitoneal injection using an adequate method, we obtained a regularly reproducible survival time with only small deviation. Knowledge of LD 50 and survival time is the basic condition for the latter therapeutic assays.

The subcutaneous injection is particularly appropriate for the study of the metastazing process, since this survival time by far exceeds the one observed with intraperitoneal injection.

Zusammenfassung

Die experimentelle Melanomforschung hat im letzten Jahrzehnt dank den häufigen spontanen Hamstermelanomen großen Auftrieb erhalten. Die vergleichenden Untersuchungen zeigen zwischen den einzelnen Tumortypen sehr ausgeprägte Unterschiede.

Die eigenen Untersuchungen betreffen besonders die Umwandlung des soliden, spontanen Hamstermelanoms M Mel 1 in einen Ascitestumor und das nachfolgende biologische Verhalten.

Die Ascitesform läßt sowohl bei der intraperitonealen, wie auch bei der subcutanen Injektion eine genaue Bestimmung der LD 50 zu. Nach intraperitonealer Injektion ist bei geeigneter Methodik auch eine sehr regelmäßige, reproduzierbare Überlebensdauer mit nur kleiner Streuung zu erreichen. LD 50 und Überlebensdauer bilden die Voraussetzung für die späteren Therapieversuche.

Die subcutane Injektion ist für das Studium der Metastasierung ganz besonders geeignet, da die Überlebensdauer gegenüber der intraperitonealen Injektion deutlich verlängert ist.

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Literatur

  • Algire, G. H.: Growth and pathology of melanoma S 91 in mice of strains dba, A, and C. J. nat. Cancer Inst. 5, 151–160 (1944).

    Google Scholar 

  • Banfield, W. G.: Persönliche Mitteilung (1967).

  • Bertalanfey, F. D., and Ch. McAskill: Rate of cell division of malignant mouse melanoma B 16. J. nat. Cancer Inst. 32, 535–555 (1964).

    Google Scholar 

  • Bloch, B.: Les naevocarcinomes. Presse méd. 31, 714 (1923).

    Google Scholar 

  • Blois, M. S., and R. F. Kallman: The incorporation of C14 from 3,4-Dihydroxyphenylalanine-2′-C14 into the melanin of mouse melanomas. Cancer Res. 24, 863–868 (1964).

    Google Scholar 

  • Bomirski, A., T. Dominiczak, and L. Nowinska: Spontaneous transplantable melanoma in the golden hamster (mesocricetus auratus). Acta Un. int. Cancr. 18, 178–180 (1962).

    Google Scholar 

  • —, L. Nowinska, and F. Pautsch: The tyrosine-positive amelanotic melanoma in the golden hamster. Structure and control of the melanocyte, p. 252–259. Edition by G. Della Porta and O. Mühlbock. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Cloudman, A. M.: The Effect of an extra-chromosomal influence upon transplanted spontaneous tumors in mice. Science 93, 380–381 (1941).

    Google Scholar 

  • Costachel, O., I. Popp e S. Dumitrescu: Risultati preliminari nell' applicazione del polipassaggio tumorale su modelli di metastasi sperimentali. Cult. med. (Roma) 37, 139–164 (1964).

    Google Scholar 

  • Fortner, J. G.: Spontaneous tumors, including gastrointestinal neoplasms and malignant melanomas, in the Syrian hamster. Cancer 10, 1153–1156 (1957).

    Google Scholar 

  • —: The production of skin lesions and lymphocytic leukemia in the Syrian (golden) hamster. Brit. J. Cancer. 19, 620–626 (1965).

    Google Scholar 

  • Fortner, J. G., A. G. Mahy, and G. R. Schrodt: Transplantable tumors of the Syrian (golden) hamster. Part I: Tumors of the alimentary tract, endocrine glands and melanomas. Cancer Res. (Suppl.) 161–198 (1961).

  • Greene, H. S. N.: A spontaneous melanoma in the hamster with a propensity for amelanotic alteration and sarcomatous transformation during transplantation. Cancer Res. 18, 422–425 (1958).

    Google Scholar 

  • —, and E. K. Harvey: The growth and metastasis of amelanotic melanomas in heterologous hosts. Cancer Res. 26, 706–714 (1966).

    Google Scholar 

  • Haaland, M.: Spontaneous tumours in mice. Fourth scientific report of the Imperial Cancer Research Fund 9, 1 (1911).

    Google Scholar 

  • Harding, H. E., and R. D. Passey: A transplantable melanoma of the mouse. J. Path. Bact. 33, 417–427 (1930).

    Google Scholar 

  • Loustalot, P., G. H. Algire, F. Y. Legallais, and B. F. Anderson: Growth and histopathology of melanotic and amelanotic derivatives of the Cloudman melanoma S 91. J. nat Cancer Inst. 12, 1079–1117 (1952).

    Google Scholar 

  • Miescher, G.: Melanom. Handbuch der Haut- und Geschlechtskrankheiten, Bd. 12, 3. Teil, S. 1005–1135. Berlin: Springer 1933.

    Google Scholar 

  • Miotti, R.: Die Lymphknoten und Lymphgefäße des syrischen Goldhamsters. Acta anat. (Basel) 46, 192–216 (1961).

    Google Scholar 

  • Ott, F., u. H. Storck: Methode der quantitativen Transplantation beim Hamster-Melanom in der Ascitesform. Dermatologica (Basel) 130, 325–331 (1965).

    Google Scholar 

  • Rivière, M.-R., B. Oberman, I. Chouroulinkov et M. Guerin: Etude anatomopathologique et comportement biologique d'un mélanome (M. 622) greffable et métastasant du hamster doré. Bull. Ass. franç. Cancer 49, 44–72 (1962).

    Google Scholar 

  • Rosenberg, J. C., C. Assimacoupoulos, P. Lober, S. A. Rosenberg, and B. Zimmermann: The malignant melanoma of hamsters. I. Pathologic characteristics of a transplanted melanotic and amelanotic tumor. Cancer Res. 21, 627 to 631 (1961)

    Google Scholar 

  • Salamon, T., u. H. Storck: Über die Sensibilität des Hamstermelanoms gegenüber Röntgenstrahlen, Kälte, Cytostatica und immunbiologischen Einflüssen. Arch. klin. exp. Derm. 216, 161–185 (1963).

    Google Scholar 

  • Schreck, E.: A method for counting the viable cells in normal and malignant cell suspension. Amer. J. Cancer. 28, 389–392 (1936).

    Google Scholar 

  • Schroeder, U.: Transplantationsversuche eines Spontantumors beim Goldhamster. Zbl. allg. Path. path. Anat. 102, 74 (1961).

    Google Scholar 

  • Snell, G. D.: A cytosieve permitting sterile preparation of suspensions of tumor cells for transplantation. J. nat. Cancer Inst. 13, 1511–1515 (1953).

    Google Scholar 

  • Storck, H.: Die Strahlentherapie der malignen Melanome. In: Handbuch der medizinischen Radiologie. Berlin-Heidelberg-New York: Springer (im Druck).

  • Strong, L. C.: The non-genetic appearance of various types of neoplasia in experimental animals. J. Cancer Res. 12, 208–221 (1928).

    Google Scholar 

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  1. Dermatologische Universitätsklinik Zürich, Zürich, Schweiz

    Fritz Ott

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Ott, F. Das Hamstermelanom M Mel 1 als Ascitestumor. Arch. klin. exp. Derm. 234, 362–383 (1969). https://doi.org/10.1007/BF00508334

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  • DOI: https://doi.org/10.1007/BF00508334

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