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On the action of nifedipine under conditions of variable stimulation patterns and [Ca2+]0 in guinea-pig atrium

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Summary

The effect of nifedipine is studied in perfused isolated guinea-pig left atrium at a temperature of 37° C and a stimulation rate between 60 and 240/min. Rhythmical stimulation at 240/min was interrupted by interposed stimulus intervals (test intervals) in a range of 0.1–4 s. The pressure amplitudes developed during subsequent test contractions rise up to a maximum with increasing test intervals. This time course is described as restitution in contractile response.

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Authors and Affiliations

  1. Physiologisches Institut der Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany

    KL. Baumann

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  1. KL. Baumann
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A preliminary report of this study has already been presented to the 45th meeting of the “Deutsche Physiologische Gesellschaft”, Wien, September 1975 (Pflügers Arch., Suppl. 359, R24, 1975)

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Baumann, K. On the action of nifedipine under conditions of variable stimulation patterns and [Ca2+]0 in guinea-pig atrium. Naunyn-Schmiedeberg's Arch. Pharmacol. 294, 161–168 (1976). https://doi.org/10.1007/BF00507849

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  • DOI: https://doi.org/10.1007/BF00507849

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