Summary
It had been shown previously that in rat vas deferens prostaglandins fail to influence neurochemical transmission. Therefore, this preparation provides a possibility for studying the transmitter release in a preparation in which any interaction with prostaglandins was in all likelihood excluded.
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1.
The inhibitory effect of α-adrenoceptor stimulation by either noradrenaline, BAY-1470 or clonidine on the response of rat vas deferens and guinea-pig atria to field stimulation depended on the rate of stimulation and on the length of train applied. The higher the frequency and the longer the train the smaller was the inhibition.
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2.
Direct evidence for the presynaptic inhibitory effect of α-adrenoceptor stimulation on transmitter release has also been provided by measuring the release of 3H-noradrenaline; there was a reduction at 2 Hz stimulation, but not at 50 Hz.
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Vizi, E.S., Somogyi, G.T., Hadházy, P. et al. Effect of duration and frequency of stimulation on the presynaptic inhibition by α-adrenoceptor stimulation of the adrenergic transmission. Naunyn-Schmiedeberg's Arch. Pharmacol. 280, 79–91 (1973). https://doi.org/10.1007/BF00505357
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DOI: https://doi.org/10.1007/BF00505357