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Verlaufsuntersuchungen unspezifischer Immunparameter bei Patienten mit Kopf-Hals-Karzinomen

Investigations of unspecific immune reactivity in patients with head and neck carcinoma

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Summary

Unspecific cellular immune reactivity in 30 patients with squamous cell carcinoma of the head and neck was compared with those in 30 healthy controls. Assays were performed in vitro to evaluate the blastogenic response of lymphocytes to the mitogens PHA (phytohemagglutinin), Con A (Concanavalin A) and PWM (pokeweed mitogen) and to quantify T-rosette-forming lymphocytes. The in vivo assay used was the delayed cutaneous hypersensitivity reaction to DNCB (dinitro-chlor-benzene). Tests were performed in all patients every 4 weeks either for a total of 1 year or until death. Tumor patients were followed up for 5 years. Compared to healthy controls tumor patients demonstrated significant impairment of unspecific immune reactivity. Surgery, chemotherapy, and radiotherapy led temporarily to a further decrease of immune reactivity. There was no correlation between unspecific immune reactivity and tumor stage, course of the disease, and prognosis. It was not possible to give any useful statement for patients with squamous cell carcinoma of the head and neck by determining their unspecific immune reactivity.

Zusammenfassung

Bei 30 Patienten mit Plattenepithel-Karzinomen im Kopf-Hals-Bereich und 30 gesunden Kontrollpersonen wurden unspezifische Immunparameter bestimmt (Lymphozytenstimulation mit PHA, ConA, PWM; relativer und absoluter T-Zell-Anteil; Hautreaktivität auf DNCB). Die Untersuchungen wurden bei jedem Patienten in vierwöchigem Intervall für mindestens ein Jahr durchgeführt. Die Tumorpatienten wurden klinisch über fünf Jahre regelmäßig nachuntersucht. Für Patienten mit Kopf-Hals-Karzinomen ließ sich gegenüber gesunden Kontrollpersonen eine verminderte unspezifische Immunreaktivität nachweisen.

Jede Behandlungsart (Chirurgie, Chemotherapie, Strahlentherapie) führte zu einer weiteren, vorübergehenden Abnahme der geprüften Parameter. Eine Abhängigkeit zwischen unspezifischen Immunparametern und Tumorstadium, klinischem Verlauf der Erkrankung und Prognose konnte nicht nachgewiesen werden. Ein Vergleich der unspezifischen Immunreaktivität zwischen Patienten mit Kopf-Hals-Karzinomen und Alkoholikern zeigte keine Unterschiede. Es war nicht möglich auf Grund der durchgeführten Untersuchungen eine klinisch relevante Aussage zu machen. Es wird in Frage gestellt, ob die untersuchten Parameter überhaupt in einen Zusammenhang mit der Tumorerkrankung stehen.

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Abbreviations

UICC:

Union Internationale Contre le Cancer

PHA:

Phytohämagglutinin

ConA:

Concanavalin A

PWM:

Pokeweed mitogen

DNCB:

Dinitrochlorbenzol

cpm:

counts per minute

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Authors and Affiliations

  1. Abteilung für Kiefer- und Plastische Gesichtschirurgie, Universitätsklinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45

    Jürgen Bier & Ulrike Nicklisch

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  1. Jürgen Bier
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  2. Ulrike Nicklisch
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Bier, J., Nicklisch, U. Verlaufsuntersuchungen unspezifischer Immunparameter bei Patienten mit Kopf-Hals-Karzinomen. Arch Otorhinolaryngol 232, 145–163 (1981). https://doi.org/10.1007/BF00505034

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  • DOI: https://doi.org/10.1007/BF00505034

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