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A new application of thin-layer chromatography. Chemical reactions induced on the adsorbent

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Summary

A new application of the chromatoplate technique is reported in which a chemical reaction can be induced on a chromatographic adsorbent under controlled conditions. The products of the reaction can then be resolved in a conventional thinlayer chromatographic procedure and compared with the expected substances on the same chromatogram. Several types of model compounds were subjected to some common reactions: acetylation, saponification, oxidation, reduction, hydrogenation, bromination, nitration, esterification, etherification, mineral acid treatment, chloride formation, acetonide formation and 2,4-dinitrophenylhydrazone formation.

Zusammenfassung

Es wird eine neue Anwendung der dünnschichtchromatographischen Technik beschrieben, bei der auf dem Adsorbens unter kontrollierten Bedingungen eine chemische Reaktion durchgeführt wird. Die Reaktionsprodukte können dann anschließend chromatographiert und mit einer entsprechenden Musterprobe verglichen werden. Mit verschiedenartigen Verbindungstypen wurden folgende Reaktionen ausgeführt: Acetylierung, Verseifung, Oxydation, Reduktion, Hydrierung, Bromierung, Nitrierung, Veresterung, Bildung von Äthern, Chloriden, Acetonderivaten und 2,4-Dinitrophenylhydrazonen, sowie Behandlung mit Mineralsäuren.

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Authors and Affiliations

  1. National Research Centre, Dokki, Cairo, U.A.R.

    M. H. A. Elgamal & M. B. E. Fayez

Authors
  1. M. H. A. Elgamal
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  2. M. B. E. Fayez
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Elgamal, M.H.A., Fayez, M.B.E. A new application of thin-layer chromatography. Chemical reactions induced on the adsorbent. Z. Anal. Chem. 226, 408–417 (1967). https://doi.org/10.1007/BF00503690

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  • DOI: https://doi.org/10.1007/BF00503690

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