Summary
Dopamine (0.5–100 μM) as well as apomorphine (1–100 μM) were found to be potent stimulators of adenylate cyclase in homogenates of rabbit retina. When compared with the dopamine-effect at 10 μM, half-stimulation was also obtained in response to noradrenaline or adrenaline, whereas isoprenaline or phenylephrine were ineffective. Furthermore, the dopamine-induced production of cyclic AMP was blocked by chloropromazine and haloperidol. These data would suggest the occurence of a specific “dopamine receptor” in the retina of the rabbit.
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Bucher, M.B., Schorderet, M. Dopamine- and apomorphine-sensitive adenylate cyclase in homogenates of rabbit retina. Naunyn-Schmiedeberg's Arch. Pharmacol. 288, 103–107 (1975). https://doi.org/10.1007/BF00501818
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DOI: https://doi.org/10.1007/BF00501818