Summary
The isolated perfused pancreas obtained from rats treated with thyroxine (600 μg/kg/day, for five days) showed a modified insulin secretory pattern. Glucose (300 mg/100 ml) induced a higher first peak of insulin secretion which appeared slightly faster than in controls. The delayed second peak, as induced by glucose in the normal rat pancreas was absent after thyroxine treatment. Tolbutamide (20 mg/100 ml) yielded a slightly higher first peak followed by a moderately increased basal insulin secretion in the treated group.
References
Andreani, D., Menzinger, G., Fallucca, F., Aliberti, G., Tamburrano, G., Cassano, C.: Insulin levels in thyrotoxicosis and primary myxoedema: Response to intravenous glucose and glucagon. Diabetologia 6, 1–7 (1970)
Curry, D. L., Bennett, L. L., Grodsky, G. M.: Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology 83, 572–584 (1968)
Grodsky, G. M., Batts, A. A., Bennett, L. L., Vcella, G., McWilliams, N. B., Smith, P. F.: Effects of carbohydrates on secretion of insulin from isolated rat pancreas. Amer. J. Physiol. 205, 638–644 (1963)
Houssay, B. A.: The action of the thyroid on diabetes. Recent Progr. Hormone Res. 2, 277–291 (1948)
Malaisse, W. J., Malaisse-Lagae, F., McCraw, E. F.: Effects of thyroid function upon insulin secretion. Diabetes 16, 643–646 (1967)
Renauld, A., Pinto, J. E. B., Sverdlik, R. C., Foglia, V. G.: Studies on the effect of hyperthyroidism on the insulin response to hyperglycemia in the dog. horm. Metab. Res. 3, 247–251 (1971)
Zaharko, D. S., Beck, L. V.: Studies of a simplified plasma insulin immunoassay using cellulose powder. Diabetes 17, 444–457 (1968)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lenzen, S., Hasselblatt, A. The effect of thyroxine treatment on the dynamics of insulin release from the isolated perfused rat pancreas. Naunyn-Schmiedeberg's Arch. Pharmacol. 282, 317–321 (1974). https://doi.org/10.1007/BF00501240
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00501240