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Decreased phalloidin response, phallotoxin uptake and bile acid transport in hepatocytes prepared from wistar rats treated chronically with diethylnitrosamine

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Summary

Isolated hepatocytes prepared from rats pretreated with diethylnitrosamine (0.5 mg/kg DENA/day p.o.) are less sensitive to phalloidin poisoning. They take up lower amounts of both phallotoxins and bile acids than controls. The degree of inhibition depends on the period of pretreatment.

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References

  • Agostini, B., Hofmann, W.: Morphology of phalloidin intoxication. In: Membrane alterations as basis of liver injury (H. Popper, L. Bianchi, W. Reutter, eds.), pp. 277–292. Lancaster, U.K.: MTP Press Ltd. 1977

    Google Scholar 

  • Agostini, B., Wieland, Th., Ivankovic, S., Hofmann, W.: Phalloidin tolerance in rats with liver carcinoma induced by diethylnitrosamine. Naturwissenschaften 63, 438 (1976)

    Google Scholar 

  • Agostini, B., Ivankovic, S., Hofmann, W.: Different response to phalloidin in rats with various hepatomas. Naturwissenschaften 64, 650 (1977)

    Google Scholar 

  • Grundmann, E., Petzinger, E., Frimmer, M., Boschek, C.B.: A possible reason for the phalloidin tolerance of hepatoma cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 305, 253–259 (1978)

    Google Scholar 

  • Kroker, R., Anwer, M.S., Hegner, D.: The lack of active bile acid transport in AS-30D ascites hepatoma cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 303, 299–301 (1978)

    Google Scholar 

  • Petzinger, E., Ziegler, K., Frimmer, M.: Inhibition of 3H-Demethylphalloin uptake in isolated rat hepatocytes under various experimental conditions. Naunyn-Schmiedeberg's Arch. Pharmacol. 307, 275–281 (1979)

    Google Scholar 

  • Ziegler, K., Petzinger, E., Grundmann, E., Frimmer, M.: Decreased sensitivity of isolated hepatocytes from baby rats, from regenerating and from poisoning livers to phalloidin. Naunyn-Schmiedeberg's Arch. Pharmacol. 306, 295–300 (1979)

    Google Scholar 

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Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie im Fachbereich Veterinärmedizin und Tierzucht der Justus-Liebig-Universität Giessen, Frankfurter Strasse 107, D-6300, Giessen, Federal Republic of Germany

    K. Ziegler, E. Petzinger & M. Frimmer

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  1. K. Ziegler
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  2. E. Petzinger
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  3. M. Frimmer
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This work was supported by the Deutsche Forschungsgemeinschaft.

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Ziegler, K., Petzinger, E. & Frimmer, M. Decreased phalloidin response, phallotoxin uptake and bile acid transport in hepatocytes prepared from wistar rats treated chronically with diethylnitrosamine. Naunyn-Schmiedeberg's Arch. Pharmacol. 310, 245–247 (1980). https://doi.org/10.1007/BF00499918

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  • DOI: https://doi.org/10.1007/BF00499918

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