Summary
Intraperitoneal injection of the (+)-erythro isomer of 3,4-dihydroxyphenylserine (DOPS) to rats markedly increased the concentration of cerebral noradrenaline (NA) which probably corresponds to the unnatural (+) form. In contrast, the other 3 stereoisomers of DOPS caused only a minor rise of NA. This difference is likely to be connected with the configuration of the stereoisomers at the α and β carbon which determines the rate of decarboxylation and possibly of penetration into the brain.
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Puig, M., Bartholini, G. & Pletscher, A. Formation of noradrenaline in the rat brain from the four stereoisomers of 3,4-dihydroxyphenylserine. Naunyn-Schmiedeberg's Arch. Pharmacol. 281, 443–446 (1974). https://doi.org/10.1007/BF00499439
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DOI: https://doi.org/10.1007/BF00499439