Summary
A gas chromatographic method for the determination of phenprocoumon (Marcumar®) in serum and urine is described, which facilitates accurate values down to 0.5 μg phenprocoumon/ml serum. After the i.v. administration of 20 mg phenprocoumon in a single dose to 4 healthy volunteers the following pharmacokinetic data were obtained:
After the initial fast decrease (phase 1) of the serum level of phenprocoumon, probably due to the distribution into the different compartments is followed by a subsequent slower fall (phase 2) which occurs with a serum half-life of 157 h. The apparent distribution volume was 6.51. Analysis of the urine demonstrated that 90% of the excreted phenprocoumon detected was in the glucuronide form.
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This study was supported by a grant from the Deutsche Forschungsgemeinschaft.
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Heni, N., Glogner, P. Pharmacokinetics of phenprocoumon in man investigated using a gas chromatographic method of drug analysis. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 183–186 (1976). https://doi.org/10.1007/BF00499225
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DOI: https://doi.org/10.1007/BF00499225