Abstract
A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activity trait corresponding to Np-2 was inherited in an autosomal codominant manner and minor differences were apparent in thermal and kinetic properties between low- and high-activity strains. This work provides further support for there being either two structural loci for purine nucleoside phosphorylase, Np-1 and Np-2, or a regulatory-modifier locus.
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This work was supported by Medical Research Council of Canada Grant MA-6376.
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Snyder, F.F., Biddle, F.G., Lukey, T. et al. Genetic variability of purine nucleoside phosphorylase activity in the mouse: Relationship to Np-1 and Np-2. Biochem Genet 21, 323–332 (1983). https://doi.org/10.1007/BF00499142
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DOI: https://doi.org/10.1007/BF00499142