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Freie Aminosäuren in Ichthyosis-Schuppen und in Callus

Free amino acids in ichthyotic scales and in callus

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Summary

The compositions of free amino acids of the cornified products, here investigated, were different from the one of normal horny layer. All hyperkeratotic materials showed generally increased amounts of lysine, leucine and isoleucine in relation to the other amino acids. In callus, citrulline was found markedly reduced, but ornithine and aspartic acid were increased. Only in sex-linked ichthyosis, serine was diminished significantly, with which this variety is to differentiate from the other ones.

Zusammenfassung

Die freien Aminosäuren aller hier untersuchten Verhornungs-produkte unterscheiden sich in ihrer Zusammensetzung von normaler Hornschicht. Gemeinsam ist den hyperkeratotischen Materialien eine Vermehrung von Lysin, Leucin und Isoleucin gegenüber den anderen Aminosäuren. In Callus war Citrullin deutlich reduziert, aber Ornithin und Asparaginsäure vermehrt. Nur bei der geschlechtsgebundenen Ichthyosis war Serin signifikant vermindert, wodurch diese von den anderen Ichthyosis-Formen unterschieden werden kann.

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Authors and Affiliations

  1. Hautklinik im Klinikum Steglitz der Freien Universität Berlin, Berlin, Deutschland

    E. Schwarz & W. Thies

  2. Hauptlaboratorium der Schering AG, Berlin

    G. Kloss

Authors
  1. E. Schwarz
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  2. W. Thies
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  3. G. Kloss
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Die Arbeit wurde dankenswerterweise aus Mitteln der Deutschen Forschungsgemeinschaft unterstützt.

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Schwarz, E., Thies, W. & Kloss, G. Freie Aminosäuren in Ichthyosis-Schuppen und in Callus. Arch. klin. exp. Derm. 235, 43–52 (1969). https://doi.org/10.1007/BF00498774

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  • DOI: https://doi.org/10.1007/BF00498774

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