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A review and update of animal toxicoses associated with fumonisin-contaminated feeds and production of fumonisins by Fusarium isolates

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Abstract

During the 1989 corn harvest season, numerous reports of equine leukoencephalomalacia (ELEM) outbreaks and a pulmonary edema (PPE) syndrome in swine from several regions of the United States were received by the National Veterinary Services Laboratories (NVSL), Ames, Iowa. Previous and concurrent research linked Fusarium moniliforme and fumonisin-contaminated feeds to both diseases. Chemical and mycological investigations revealed fumonisin B1 (FB1) concentrations of 20 to 360 ppm in suspect swine feeds and 8 to 117 ppm in suspect equine feeds. Nonproblem feeds contained concentrations below 8 ppm. Fusarium moniliforme and Fusarium proliferatum were isolated from both problem and nonproblem equine and swine feeds. When cultured on autoclaved corn, the F. moniliforme and F. proliferatum isolates produced respective FB1 and fumonisin B2 (FB2) that range from less than 5 to more than 2450 ppm and less than 5 to more than 1000 ppm, respectively. Isolates from both problem and nonproblem feeds produced high levels (greater than 500 ppm) in culture. Reported here is a review of chemical and mycological data resulting from the study of several cases of PPE and ELEM.

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Authors and Affiliations

  1. Animal and Plant Health Inspection Service, Science and Technology, National Veterinary Services Laboratories, USDA, 50010, Ames, IA, USA

    P. Frank Ross, Larry G. Rice & Terrance M. Wilson

  2. Veterinary Diagnostic Laboratory, Iowa State University, College of Veterinary Medicine, 50011, Ames, IA, USA

    Gary D. Osweiler

  3. The Fusarium Research Center, Department of Plant Pathology, Pennsylvania State University, University Park, 16802, PA, USA

    Paul E. Nelson

  4. National Center for Agricultural Utilization Research, USDA/ARS, 61604, Peoria, IL, USA

    John L. Richard

Authors
  1. P. Frank Ross
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  2. Larry G. Rice
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  3. Gary D. Osweiler
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  4. Paul E. Nelson
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  5. John L. Richard
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  6. Terrance M. Wilson
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Ross, P.F., Rice, L.G., Osweiler, G.D. et al. A review and update of animal toxicoses associated with fumonisin-contaminated feeds and production of fumonisins by Fusarium isolates. Mycopathologia 117, 109–114 (1992). https://doi.org/10.1007/BF00497286

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  • DOI: https://doi.org/10.1007/BF00497286

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