Summary
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1.
The influence of weak mechanical stimulation of the jejunal mucosa in vivo on PGE-release, on intestinal blood flow and transmucosal water movement was studied in rats.
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2.
Mechanical stimulation of the mucosa increased PGE-release into the venous outflow and into the gut lumen. This increase is followed by an increase in intestinal blood flow and transmucosal movement of tritiated water in both directions.
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3.
Pretreatment of the rat with idomethacin reduced the effect of mechanical stimulation on PGE-release. Indomethacin further reduced the increase in blood flow and in secretion of tritiated water. Absorption of tritiated water was not changed in these experiments.
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4.
Pretreatment of the rat with atropine (1 mg/kg, i.p.) or perfusion of the gut with methysergide (10 μg/ml) did not influence the increase in intestinal blood flow after mechanical stimulation.
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5.
It is suggested that enhanced intestinal blood flow and transmucosal movement of tritiated water after mechanical stimulation are mainly provoked by a preceding release of PGE.
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6.
It is further supposed that such a mechanism may be physiologically involved in regulation of intestinal blood flow and transmucosal water movement during food intake.
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Preliminary report: Venezia Joint Meeting of German and Italian Pharmacological Societies, Venezia 1977
Supported by the Fonds zur Förderung der wissenschaftlichen Forschung in Österreich, Project Nr. 3630
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Beubler, E., Juan, H. PGE-release, blood flow and transmucosal water movement after mechanical stimulation of the rat jejunal mucosa. Naunyn-Schmiedeberg's Arch. Pharmacol. 305, 91–95 (1978). https://doi.org/10.1007/BF00497010
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DOI: https://doi.org/10.1007/BF00497010