Abstract
Rats were trained to self-stimulate by interrupting a photobeam and brain stimulation was maintained for as long as the beam of light was broken. d-Amphetamine sulphate was then administered and response rate and total duration of stimulation were recorded. Both response rate and total duration were elevated by 1.0, 2.0, and 5.0 mg/kg dosages. The 1.4 s/response duration observed with saline was elevated to 2.0 s/response with 2.0 and 5.0 mg/kg doses. It was concluded that amphetamine's effects on self-stimulation are at least partially determined by the response requirements of the task employed.
This is a preview of subscription content, log in via an institution to check access.
References
Danielson, T. J., Wishart, T. B., Boulton, A. A.: Effect of acute and chronic injection of d-amphetamine sulphate on intracranial self-stimulation (ICS) and some aryl alkyl amines in the rat brain. Life Sci. 18, 1237–1244 (1976)
Domino, E. F., Olds, M. E.: Effects of d-amphetamine, scopolamine, chlordiazepoxide and diphenylhydantoin on self-stimulation behavior and brain acetylcholine. Psychopharmacologia 23, 1–16 (1972)
Lyon, M., Randrup, A.: The dose-response effect of amphetamine upon avoidance behavior in the rat as a function of increasing stereotypy. Psychopharmacologia 23, 334–347 (1972)
Stein, L., Wise, C. D.: Release of norepinephrine from hypothalamus and amygdala by rewarding and medial forebrain bundle stimulation and amphetamine. J. Comp. Physiol. Psychol. 67, 189–198 (1969)
Stein, L., Wise, C. D.: Behavioral pharmacology of central stimulants. In: Principles of psychopharmacology, W. G. Clark ed., pp. 313–325. New York: Academic 1970
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zacharko, R.M., Wishart, T.B. Facilitation of self-stimulation with high doses of amphetamine in the rat. Psychopharmacology 64, 247–248 (1979). https://doi.org/10.1007/BF00496071
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00496071