Abstract
The effects of abrupt and gradual withdrawal from long-term haloperidol treatment on rat open field behavior was studied. Abrupt withdrawal induced a significant increase in all parameters of activity observed except defecation, this increase being higher 72 h after the last haloperidol injection. Results were considered to be a consequence of supersensitivity of central dopaminergic receptors. These differences were almost unobservable in animals gradually withdrawn, thus suggesting that the phenomenon is reversible.
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Bernardi, M.M., Neto, J.P. Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open field behavior of rats. Psychopharmacology 65, 247–250 (1979). https://doi.org/10.1007/BF00492211
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DOI: https://doi.org/10.1007/BF00492211