Abstract
The effects of increasing the brain monoamine content on the three types of localized rhythms identified in somatic area I (‘mu-type rhythms’) were studied in freely moving cats.
Increases in brain monoamines (catecholamines and serotonin) were produced by injecting l-Dopa and 5-HTP. l-tyrosine, l-tryptophan and tryptamine were also tested.
It is concluded that the two subsets of rhythms, one accompanying high levels of alertness and vigilance and the other appearing during quiet wakefulness, are related to the catecholaminergic systems, while those characterizing drowsiness seem to be controlled by a serotoninergic system. The latter, however, is distinct from that controlling slow sleep.
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References
Bertler, A., Rosengren, E.: Occurrence and distribution of catecholamine in brain. Act Physiol. Scand. 47, 350–361 (1959a)
Bertler, A., Rosengren, E.: On the distribution in brain of monoamines and of enzymes responsible for their formation. Experientia, Basel 15, 328–384 (1959b)
Bouyer, J. J., Dedet, L., Verdeux, J., Rougeul, A.: Selective modification of spontaneous ECoG rhythms of the cat somesthetic cortex by psychoactive drugs: behavioral correlates. Psychopharmacology 55, 237–242 (1977)
Chatrian, G. E., Petersen, M. C., Lazarte, J. A.: The blocking of the rolandic wicket rhythm and some central changes related to movement. Electroencephalogr. Clin. Neurophysiol. 11, 497–510 (1959)
Dahlström, A., Fuxe, K.: Evidence for the existence of monoamine-containing neurons in the central nervous system. II. Experimentally induced changes in the intraneural amine levels of bulbo-spinal neuron systems. Acta Physiol. Scand. 64, Suppl. 247, 5–36 (1965)
Galey, D., Simon, H., Le Moal, M.: Behavioral effects of lesions in the A10 dopaminergic area of the rat. Brain Res. 124, 83–97 (1977)
Gastaut, H., Jus, A., Jus, C., Morell, F., Storm van Leeuwen, W., Dongier, S., Naquet, R., Regis, H., Roger, A., Bekkering, D., Kamp, A., Werre, J.: Etude topographique des réactions électroencéphalographiques conditionnées chez l'homme. Electroencephalogr. Clin. Neurophysiol. 9, 1–34 (1957)
Gessa, G. L., Costa, E., Kuntzman, R., Brodie, B. B.: Evidence that the loss of brain catecholamine stores due to blockade of storage does not cause sedation. Life Sci. 11, 605–616 (1962)
Hess, S. M., Redfield, B. G., Udenfriend, S.: The effect of monoamine oxidase inhibitors and trytophan on tryptamine content of aminal tissues and urine. J. Pharmacol. 127, 178–181 (1959)
Liechensteiger, W., Mutzner, U., Langermann, H.: Uptake of 5-hydroxytryptamine and 5-hydroxytryptophan by neurons of central nervous system normally containing catecholamines. J. Neurochem. 14, 489–497 (1967)
Lovenberg, W., Weissbach, H., Udenfriend, S.: Aromatic l-amino acid decarboxylase. J. Biol. Chem. 237, 89–93 (1962)
McGeer, P. L., McGeer, E. G., Wada, J. A.: Central aromatic amine levels and behaviour. II. Serotonin and catecholamine levels in various cat brain areas following administration of psychoactive drugs or amine precursors. Arch. Neurol. 9, 81–89 (1963)
McKean, C. M., Boggs, D. E., Peterson, N. A.: The influence of high phenylalanine and tyrosine on the concentration of essential amino-acids in brain. J. Neurochem. 15, 235–241 (1968)
Pickworth, W. B., White, R. P.: Tryptamine: bimodal actions on the EEG and behavior of rabbits. Arch. Int. Pharmacodyn. 225, 64–76 (1977)
Pujol, J. F.: Contribution à l'étude des modifications de la régulation du métabolisme des monoamines centrales pendant le sommeil et la veille. Thèse Doct. Sci., Paris 1970
Rougeul-Buser, A., Bouyer, J. J., Buser, P.: From attentiveness to sleep. A topographical analysis of localized ‘synchronized’ activities on the cortex of normal cat and monkey. Acta Neurobiol. Exp. 35, 805–819 (1975)
Scheving, L. E., Harrison, W. H., Gordon, P., Pauley, J. E.: Daily fluctuation (circadian and ultradian) in biogenic amines of rat brain. Am. J. Physiol. 214, 166 (1968)
Spooner, C. E., Winters, W. D.: Evidence for a direct action of monoamines on the chick central nervous system. Experientia 21, 256 (1965)
Trulson, M. E., Jacobs, B. L.: Dose-response relationships between systematically administered l-tryptophan or l-5-hydroxytryptophan and raphe unit activity in the rat. Neuropharmacology 15, 339–344 (1976)
Vogt, M.: Cerebral tryptamine receptors: functional considerations. In: Advances in pharmacology, Vol. 6B, S. Garattini and P. A. Shore, eds., pp. 19–25, New York: Acad. Press 1968
Weil-Malherbe, H., Posner, H. S., Bowles, G. R.: Changes in concentrations and intracellular distribution of brain catecholamines: the effect of reserpine, β-phenyl-isopropylhydrazine, pyrogallol and 3-4-dihydroxyphenylalanine, alone or in combination. J. Pharmacol. 132, 278–285 (1961)
Wintman, R. J., Fernstrom, J. D.: l-Tryptophan, l-tyrosine and the control of brain monoamine biosynthesis. In: Perspectives in neuropharmacology, S. H. Snyder, ed. London: Oxford Univ. Press 1972
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Bouyer, JJ., Dedet, L., Joseph, JP. et al. Modification of spontaneous ECoG and behavior in cat by monoamine precursors. Psychopharmacology 65, 49–54 (1979). https://doi.org/10.1007/BF00491977
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DOI: https://doi.org/10.1007/BF00491977