Abstract
The heredity and linkage of gene loci were established for two different enzymes with esterproteolytic activity from mouse submandibular gland: protease A and protease E. Based upon strain distribution and biochemical properties of the two esterproteases, the existence of two corresponding structural loci is proposed: Prt-4 (protease A) and Prt-5 (protease E). Prt-4 and Prt-5 proved to be different from Tam-1. From a four-point-cross, the gene order Gpi-1-(Tam-1, Prt-4, Prt-5)-c is suggested. Thus a gene cluster was shown to exist on chromosome 7 coding for esterproteases, all of which are controlled by testosterone.
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This work was supported by grants from the Deutsche Forschungsgemeinschaft, Bonn (SFB 46).
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Otto, J., von Deimling, O. Prt-4 and Prt-5: New constituents of a gene cluster on chromosome 7 coding for esterproteases in the submandibular gland of the house mouse (Mus musculus). Biochem Genet 19, 431–444 (1981). https://doi.org/10.1007/BF00484616
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DOI: https://doi.org/10.1007/BF00484616