References
Breakefield, X. O., Castiglione, C. M., and Edelstein, S. B. (1976). Monoamine oxidase activity decreased in cells lacking hypoxanthine phosphoribosyltransferase activity. Science 1921018.
Fujimoto, W. Y., and Seegmiller, J. E. (1970). Hypoxanthine-guanine phosphoribosyltransferase deficiency: Activity in normal, mutant, and heterozygote-cultured human skin fibroblasts. Proc. Natl. Acad. Sci. 65577.
Lesch, M., and Nyhan, W. L. (1964). A familial disorder of uric acid metabolism and central nervous system function. Am. J. Med. 36561.
Roth, J. A., Breakefield, X. O., and Castiglione, C. M. (1976). Monoamine oxidase and catechol-O-methyltransferase activities in cultured human skin fibroblasts. Life Sci. 191705.
Seegmiller, J. E., Rosenbloom, F. M., and Kelley, W. N. (1967). Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science 1551682.
Skaper, S. D., and Seegmiller, J. E. (1976). Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: Diminished monoamine oxidase activity. Science 1941171.
Skaper, S. D., Adelson, G. L., and Seegmiller, J. E. (1976) Metabolism of biogenic amines in neuroblastoma and glioma cells in culture. J. Neurochem. 271065.
Wood, A. M., Becker, M. A., and Seegmiller, J. E. (1973). Purine nucleotide synthesis in lymphoblasts cultured from normal subjects and a patient with Lesch-Nyhan syndrome. Biochem. Genet. 9261.
Wurtman, R. J., and Axelrod, J. E. (1963). A sensitive and specific assay for the estimation of monoamine oxidase. Biochem. Pharmacol. 121439.
Author information
Authors and Affiliations
Additional information
This work was supported by NIH Grants GM-07004 and HD-10524 and by a grant from the Cleveland Foundation.
Rights and permissions
About this article
Cite this article
Skaper, S.D., Schafer, I.A. Monoamine oxidase activity reduced in cultured human fetal cells deficient in hypoxanthine-guanine phosphoribosyltransferase activity. Biochem Genet 16, 1135–1138 (1978). https://doi.org/10.1007/BF00484533
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00484533