Abstract
A wide range of fluorogenic and naphthol esters has been tested as substrates for mouse esterases. New esterases have been identified in liver and kidney extracts with palmityl, oleyl, and elaidyl esters. From substrate, inhibition, and molecular weight studies, three homologies between human and mouse esterases are suggested. A new allele at Es-6 is also described.
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Arnason, A., and Pantelouris, E. M. (1966). Serum esterases of Apodemus sylvaticus and Mus musculus. Comp. Biochem. Physiol. 1953.
Berry, R. J., and Peters, J. (1977). Heterogeneous heterozygosities in Mus musculus populations. Proc. Roy. Soc. London Ser. B 1971.
Chapman, V. M., Nichols, E. A., and Ruddle, F. H. (1974). Esterase-8 (Es-8): Characterization, polymorphism, and linkage of an erythrocyte esterase locus on chromosome 7 of Mus musculus. Biochem. Genet. 11347.
Coates, P. M., Mestriner, M. A., and Hopkinson, D. A. (1975). A preliminary genetic interpretation of the esterase isozymes of human tissues. Ann. Hum. Genet. 391.
Hunter, R. L., and Strachan, D. S. (1961). The esterases of mouse blood. Ann. N.Y. Acad. Sci. 94861.
Martin, J. E., and Petras, M. L. (1971). Es-3 esterases in erythrocytes of Mus musculus. Can. J. Genet. Cytol. 13777.
Peters, J., and Nash, H. R. (1976). Polymorphism of esterase-10 in Mus musculus. Biochem. Genet. 14119.
Peters, J., and Nash, H. R. (1977). Polymorphism of esterase-11 in Mus musculus, a further esterase locus on chromosome 8. Biochem. Genet. 15217.
Petras, M. L. (1963). Genetic control of a serum esterase component in Mus musculus. Proc. Natl. Acad. Sci. 50112.
Petras, M. L., and Biddle, F. G. (1967). Serum esterases in the house mouse, Mus musculus. Can. J. Genet. Cytol. 9704.
Petras, M. L., and Sinclair, P. (1969). Another esterase variant in the kidney of the house mouse, Mus musculus. Can. J. Genet. Cytol. 1197.
Popp, R. A. (1966). Inheritance of an erythrocyte and kidney esterase in the mouse. J. Hered. 57197.
Popp, R. A., and Popp, D. M. (1962). Inheritance of serum esterases having different electrophoretic patterns among inbred strains of mice. J. Hered. 53111.
Roderick, T. H., Hutton, J. J., and Ruddle, F. H. (1970). Linkage of esterase-3 and Rex on linkage group VII of the mouse. J. Hered. 61278.
Ruddle, F. H., and Roderick, T. H. (1966). The genetic control of two types of esterases in inbred strains of the mouse. Genetics 54191.
Ruddle, F. H., and Roderick, T. H. (1968). Allelically determined isozyme polymorphisms in laboratory populations of mice. Ann. N.Y. Acad. Sci. 151531.
Ruddle, F. H., Shows, T. B., and Roderick, T. H. (1969). Esterase genetics in Mus musculus: Expression, linkage, and polymorphism of locus Es-2. Genetics 62393.
Schollen, J., Bender, K., and von Deimling, O. (1975). Esterase. XXI. Es-9, a possibly new polymorphic esterase in Mus musculus genetically linked to Es-2. Biochem. Genet. 13369.
Taylor, B. A. (1977). Private communication. Mouse News Letter 5640.
Templeton, M. (1969). Mouse erythrocyte esterases and an interaction with heparin as shown by starch gel electrophoresis. J. Histochem. Cytochem. 1795.
Wallace, M. E. (1976). Private communication. Mouse News Letter 5510.
Womack, J. E. (1975). Esterase-6 (Es-6) in laboratory mice: Hormone influenced expression and linkage relationship to oligosyndactylism (Os), esterase-1 (Es-1), and esterase-2 (Es-2) in chromosome 8. Biochem. Genet. 13311.
Womack, J. E., and Sharp, M. (1976). Comparative autosomal linkage in mammals: Genetics of esterase in Mus musculus and Rattus norvegicus. Genetics 82665.
Womack, J. E., Davisson, M. T., Eicher, E. M., and Kendall, D. A. (1977). Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14. Biochem. Genet. 15347.
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This work was supported by the Medical Research Council.
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Peters, J., Nash, H.R. Esterases of Mus musculus: Substrate and inhibition characteristics, new isozymes, and homologies with man. Biochem Genet 16, 553–569 (1978). https://doi.org/10.1007/BF00484219
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DOI: https://doi.org/10.1007/BF00484219