Abstract
The spatial variation in gene frequencies of four unlinked polymorphic loci was studied in the teleost Fundulus heteroclitus. Three loci (Idh-A, Idh-B, and Est-S) exhibit significant north-south clinal variation in allelic frequencies along the Atlantic Coast of North America, while a fourth locus (6-Pgdh-A) shows a modest clinal variation. These data, together with our previous data for Ldh-B, Mdh-A, Gpi-B, and Pgm-A, reveal a pattern of low gene diversity in the colder northern extremes of the species range and high gene diversity in warmer southern latitudes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brandes, W. F., Harris, J. W., and Estes, R. D. (1978). Isozyme variation in the eastern brook trout Salvelinus fontinalis (Mitchell). Assoc. S.E. Biol. Bull. 2540.
Chen, T. R. (1971). A comparative chromosome study of twenty killifish species of the genus Fundulus (Teleostei: Cyptrinodontidae.) Chromosoma (Berl.) 32436.
Christiansen, F. E., and Frydenberg, O. (1974). Geographical patterns of four polymorphisms in Zoarces viviparus as evidence of selection. Genetics 77765.
Corbin, K. W. (1977). Phosphoglucose isomerase polymorphism and natural selection in the sand crab, Emerita talpoida. Evolution 31331.
Griffith, R. W. (1972). Studies of the Physiology and Evolution of Killifishes of the Genus Fundulus Ph.D. thesis, Yale University, New Haven, Conn.
Griffith, R. W. (1974). Environment and salinity tolerance in the genus Fundulus. Copeia 1974319.
Hill, W. G. (1974). Estimation of linkage disequilibrium in randomly mating populations. Heredity 38229.
Hjorth, J. P., and Simonsen, V. (1975). Genetics of Zoarces populations. VIII. Geographic variation common to the polymorphic loci HbI and Est III. Hereditas 81173.
Huxley, J. S. (1939). Clines: An auxiliary method in taxonomy. Bijdr. Dierk. 27491.
Johnson, M. S. (1974). Comparative geographic variation in Menidia. Evolution 28607.
Kimura, M. (1978). Protein polymorphism and geographic variation in the loach Misgurnus anguillicaudatus. Animal Blood Grps. Biochem. Genet. 913.
Koehn, R. K. (1969). Esterase heterogeneity: Dynamics of a polymorphism. Science 163943.
Koehn, R. K., and Rasmussen, D. I. (1967). Polymorphic and monomorphic serum esterase heterogeneity in catostomid fish populations. Biochem. Genet. 1131.
Lewontin, R. C. (1974). The Genetic Basis of Evolutionary Change Columbia University Press, New York.
Lotrich, V. A. (1975). Summer home range and movements of Fundulus heteroclitus (Pisces: Cyprinodontidae) in a tidal creek. Ecology 56191.
Mitton, J. B., and Koehn, R. K. (1975). Genetic organization and adaptive response of allozymes to ecological variables in Fundulus heteroclitus. Genetics 7997.
Nei, M. (1975). Molecular Population Genetics and Evolution American Elsevier, New York.
Nevo, E. (1978). Genetic variation in natural populations: Patterns and theory. Theoret. Pop. Biol. 13121.
Place, A. R., and Powers, D. A. (1978). Genetic bases for protein polymorphism in Fundulus heteroclitus (L.). I. Lactate dehydrogenase (Ldh-B), malate dehydrogenase (Mdh-A), glucosephosphate isomerase (Gpi-B), and phosphoglucomutase (Pgm-A). Biochem. Genet. 16576.
Place, A. R., and Powers, D. A. (1979). Genetic variation and relative catalytic efficiencies: Lactate dehydrogenase B allozymes of Fundulus heteroclitus. Proc. Natl. Acad. Sci. USA 762354.
Powers, D. A., and Place, A. R. (1978). Biochemical genetics of Fundulus heteroclitus (L). I. Temporal and spatial variation in gene frequencies of Ldh-B, Mdh-A, Gpi-B, and Pgm-A. Biochem. Genet. 16593.
Powers, D. A., Greaney, G. S., and Place, A. R. (1979). Physiological correlation between lactate dehydrogenase genotype and haemoglobin function in killifish. Nature 277240.
Smith, P. J. (1979). Esterase gene frequencies and temperature relationships in the New England snapper Chrysophrs auratus. Mar. Biol. 53305.
Van Beneden, R. J., Cashon, R. E., and Powers, D. A. (1981). Biochemical genetics of Fundulus heteroclitus (L.). III. Genetic bases (F1) for isocitrate dehydrogenase (Idh-A and Idh-B), 6-phosphogluconate dehydrogenase (6-Pgdh-A), and serum esterase (Est-S) polymorphisms. Biochem. Genet. 19701.
Vrijenhoek, R. C., Angus, R. A., and Schutz, R. J. (1977). Variation and heterozygosity in sexually vs. clonally reproducing populations of Poeciliopsis. Evolution 31767.
Author information
Authors and Affiliations
Additional information
This work was supported by Grants DEB76-19877 and DEB79-12216 from the National Science Foundation and by Grant P60-80-04 from the State of Maryland. REC and RVB were supported by NIH Training Grant GM07231 to the Department of Biology.
Contribution No. 1104 from the Department of Biology, The Johns Hopkins University.
Rights and permissions
About this article
Cite this article
Cashon, R.E., Van Beneden, R.J. & Powers, D.A. Biochemical genetics of Fundulus heteroclitus (L.). IV. Spatial variation in gene frequencies of Idh-A, Idh-B, 6-Pgdh-A, and Est-S . Biochem Genet 19, 715–728 (1981). https://doi.org/10.1007/BF00484004
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00484004